DSpace Collection: http://hdl.handle.net/2440/4285 2013-05-18T15:04:45Z 2013-05-18T15:04:45Z Investigation of the substrate range of CYP199A4: modification of the partition between hydroxylation and desaturation activities by substrate and protein engineering Bell, Stephen Graham Zhou, Ruimin Yang, Wen Tan, Adrian B. H. Gentleman, Alexander Wong, Luet-Lok Zhou, Weihong http://hdl.handle.net/2440/76779 2013-04-10T02:30:48Z 2011-12-31T13:30:00Z Title: Investigation of the substrate range of CYP199A4: modification of the partition between hydroxylation and desaturation activities by substrate and protein engineering Author: Bell, Stephen Graham; Zhou, Ruimin; Yang, Wen; Tan, Adrian B. H.; Gentleman, Alexander; Wong, Luet-Lok; Zhou, Weihong 2011-12-31T13:30:00Z Molecular tweezers with freely rotating linker and porphyrin moieties Murphy, Rhys B. Pham, Duc-Truc Lincoln, Stephen Frederick Johnston, Martin Ross http://hdl.handle.net/2440/76743 2013-04-10T00:30:32Z 2012-12-31T13:30:00Z Title: Molecular tweezers with freely rotating linker and porphyrin moieties Author: Murphy, Rhys B.; Pham, Duc-Truc; Lincoln, Stephen Frederick; Johnston, Martin Ross Abstract: Molecular tweezers were synthesised by using a microwave accelerated alkene plus cyclobutane epoxide reaction between norbornyl appended porphyrin moieties and a diepoxide functionalised phenyl diimide spacer. The tweezers contain several rotational degrees of freedom; about the porphyrin with respect to the norbornyl linker, and between the two norbornyl backbone sections. The ability of Zn(super)II metallated tweezer 1 to complex 1,4-diazabicyclo[2.2.2]octane (DABCO) was studied by UV/Vis and ¹H NMR spectroscopy and multivariate global spectral analysis. The system was found to form a strong 1:1 intramolecular complex (1:DABCO) with an association constant of K₁₁ = 8.1 × 10⁷ M⁻¹, transforming to a 1:2 open complex [1:(DABCO)₂] with K₁₂ = 2.7 × 10⁹ M⁻² at high concentrations of DABCO. 2012-12-31T13:30:00Z Tailoring an alien ferredoxin to support native-like P450 monooxygenase activity Bell, Stephen Graham McMillan, James H. C. Yorke, Jake A. Kavanagh, Emma Johnson, Eachan O. D. Wong, Luet-Lok http://hdl.handle.net/2440/76722 2013-04-09T06:30:43Z 2011-12-31T13:30:00Z Title: Tailoring an alien ferredoxin to support native-like P450 monooxygenase activity Author: Bell, Stephen Graham; McMillan, James H. C.; Yorke, Jake A.; Kavanagh, Emma; Johnson, Eachan O. D.; Wong, Luet-Lok 2011-12-31T13:30:00Z A study on the diastereoselective synthesis of α-fluorinated β³-amino acids by α-fluorination Peddie, Victoria Abell, Andrew David http://hdl.handle.net/2440/75832 2013-04-30T00:32:10Z 2011-12-31T13:30:00Z Title: A study on the diastereoselective synthesis of α-fluorinated β³-amino acids by α-fluorination Author: Peddie, Victoria; Abell, Andrew David 2011-12-31T13:30:00Z