http://hdl.handle.net/2440/11 Search the Channel search http://digital.library.adelaide.edu.au/dspace/simple-search http://hdl.handle.net/2440/53618 Title: Interplay of spin and orbital angular momentum in the proton <br/> <br/>Author: Thomas, Anthony William <br/> <br/>Description: ©2008 The American Physical Society http://hdl.handle.net/2440/53584 Title: The enantiomer of octreotate binds to all five somatostatin receptors with almost equal micromolar affinity - A comparison with Sandostatin®. <br/> <br/>Author: Gardiner, James; Langenegger, Daniel; Hoyer, Daniel; Beck, Albert K.; Mathad, R. I.; Seebach, Dieter <br/> <br/>Abstract: Octreotate (1b) is the octreotide (SANDOSTATIN®; 1a) analogue, carrying a C-terminal CO2H (Thr) instead of the CH2OH (threoninol) group. In pursuit of our interest in unnatural peptides, we have now synthesized (by the solid-phase Fmoc method) the enantiomeric form 2 of octreotate and determined its affinity for the five human somatostatin (SRIF) receptors (hsst1-5). The binding was found to be 9.1, 4.1, 1.0, 1.4, and 4.2 M, respectively. This almost equal one-digit micromolar affinity of ent-octreotate (2) to all five receptors contrasts with the behavior of most other somatostatin mimics including SANDOSTATIN® (octreotide; 1a) and [Tyr3]-octreotate (1c), which have affinities for the various receptors differing up to and above 104-fold. Thus, the structure of the new compound does not prevent binding, albeit more weakly than its pseudo-enantiomer octreotide, and there is hardly any selectivity of the peptide-protein interaction (PPI) for any one of the five SRIF G-protein coupled receptors (GPCRs). Since the detailed structure(s) of these membrane-embedded receptors is unknown (no X-ray structure!), the result described here may be useful for modeling structures by comparing the affinities of the numerous known somatostatin mimics. http://hdl.handle.net/2440/53550 Title: The Strong-coupling limit of minimal lattace landau gauge <br/> <br/>Author: Sternbeck, Andre; Von Smekal, Lorenz Johann Maria <br/> <br/>Description: Copyright owned by the author(s) under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike Licence.; Submitted to Cornell University’s online archive www.arXiv.org in 2008 by Andre Sternbeck. http://hdl.handle.net/2440/53549 Title: Lattice Landau Gauge via Stereographic Projection <br/> <br/>Author: Von Smekal, Lorenz Johann Maria; Jorkowski, Alexander Felix; Mehta, Dhagash Bharatbhai; Sternbeck, Andre <br/> <br/>Abstract: The complete cancellation of Gribov copies and the Neuberger 0=0 problem of lattice BRST can be avoided in modified lattice Landau gauge. In compact U(1), where the problem is a lattice artifact, there remain to be Gribov copies but their number is exponentially reduced. Moreover, there is no cancellation of copies there as the sign of the Faddeev-Popov determinant is positive. Applied to the maximal Abelian subgroup this avoids the perfect cancellation amongst the remaining Gribov copies for SU(N) also. In addition, based on a definition of gauge fields on the lattice as stereographically-projected link variables, it provides a framework for gauge fixed Monte-Carlo simulations. This will include all Gribov copies in the spirit of BRST. Their average is not zero, as demonstrated explicitly in simple models. This might resolve present discrepancies between gauge-fixed lattice and continuum studies of QCD Green’s functions. <br/> <br/>Description: Copyright © owned by the author(s) under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike Licence.; Submitted to Cornell University’s online archive www.arXiv.org in 2008 by Lorenz von Smekal.