http://hdl.handle.net/2440/10015 Search the Channel search http://digital.library.adelaide.edu.au/dspace/simple-search http://hdl.handle.net/2440/56803 Title: Effects of once-daily Tadalafil on erectile function in men with erectile dysfunction and signs and symptoms of benign prostatic hyperplasia<br/><br/>Author: Porst, Hartmut; McVary, Kevin T.; Montorsi, Francesco; Sutherland, Peter D'Arcy; Elion-Mboussa, Albert; Wolka, Anne M.; Viktrup, Lars<br/><br/>Description: Copyright © 2009 European Association of Urology. Published by Elsevier B.V. Thu, 01 Jan 2009 00:00:00 GMT http://hdl.handle.net/2440/56802 Title: Impaired mucosal healing and infection associated with Staphylococcus aureus after endoscopic sinus surgery<br/><br/>Author: Jervis-Bardy, Joshua; Foreman, Andrew; Field, John Benjamin Francis; Wormald, Peter-John<br/><br/>Abstract: Background: Differentiating normal nasal discharge and postoperative crust from infection after endoscopic sinus surgery (ESS) can be difficult. We investigated whether bacteria cultured at operation was predictive for postoperative mucosal infection—defined as frank pus, thick mucus, and/or abnormal crusting seen on endoscopic examination associated with positive microbiology.Methods: The records of 48 patients with chronic rhinosinusitis (CRS) with infection at the time of ESS were retrospectively reviewed. Results of intraoperative cultures were compared with those taken at the time of postoperative mucosal infection.Results: Fourteen of 16 patients (87.5%) with intraoperative infection with Staphylococcus aureus progressed to postoperative mucosal infection with S. aureus, whereas patients who cultured “other” bacteria intraoperatively progressed to postoperative mucosal infection in 6/19 cases (31.6%), with S. aureus cultured in only 3/19 cases (15.8%; p = 0.0001).Conclusion: S. aureus infection at ESS predicts for abnormal, S. aureus-associated mucosal healing and infection post-ESS. Although a prospective trial is warranted, these findings suggest a future role for aggressive anti-S. aureus therapy peri- and/or postoperatively in patients who culture positive for this organism to improve postsurgical outcomes. Thu, 01 Jan 2009 00:00:00 GMT http://hdl.handle.net/2440/56801 Title: A systematic review of permanent and semipermanent dermal fillers for HIV-associated facial lipoatrophy<br/><br/>Author: Sturm, Lana; Cooter, Rodney Dean; Mutimer, Keith; Graham, John C.; Maddern, Guy John<br/><br/>Abstract: The objective of this study was to assess the safety and efficacy of injectable semipermanent and permanent dermal fillers, compared to other facial augmentation techniques, for the management of facial lipoatrophy as a result of highly active antiretroviral therapy (HAART) for HIV infection through a systematic review of the literature. A systematic search strategy was used to retrieve relevant studies. Inclusion of articles was by the application of a predetermined protocol, independent assessment by two reviewers, and a final consensus decision. One randomized controlled trial (RCT), one pseudo-RCT, two nonrandomized comparative studies, and seven case series were included for review. Injections with permanent and semipermanent dermal fillers improved subjective ratings of appearance and resulted in high patient satisfaction. Although short-term safety appeared favorable, of the seven studies that reported lumps, three studies reported these events in more than 40% of patients. Long-term safety data were lacking. Evidence suggests that permanent and semipermanent dermal fillers achieve their objective, which is to decrease the visible effects of HIV-associated facial lipoatrophy, with high patient satisfaction. Safety appears favorable in the short term, but further studies are required to determine long-term outcomes. Thu, 01 Jan 2009 00:00:00 GMT http://hdl.handle.net/2440/56800 Title: Characterization of bacterial and fungal biofilms in chronic rhinosinusitis<br/><br/>Author: Foreman, Andrew; Psaltis, Alkis James; Tan, Lor-Wai; Wormald, Peter-John<br/><br/>Abstract: Background: Conclusive evidence exists that biofilms are present on the mucosa of chronic rhinosinusitis (CRS) patients. Less is known about the species constituting these biofilms. This study developed a fluorescence in situ hybridization (FISH) protocol for characterization of bacterial and fungal biofilms in CRS.Methods: Fifty CRS patients and 10 controls were recruited. Bacteria FISH probes for Staphylococcus aureus, Haemophilus influenzae, and Pseudomonas aeruginosa and a universal probe for fungi were applied to sinus mucosal specimens and then analyzed using confocal scanning laser microscopy.Results: Thirty-six of 50 CRS patients had biofilms present in contrast to 0/10 controls, suggesting a role for biofilms in the pathogenesis of this disease. S. aureus was the most common biofilm-forming organism. Eleven of 50 CRS patients had characteristic fungal biofilms present.Conclusion: This is the largest study of biofilms in CRS. It has validated mucosal tissue cryopreservation for delayed biofilm analysis. Fungal biofilms have been identified and the importance of S. aureus biofilms in the polymicrobial etiology of CRS is highlighted. Thu, 01 Jan 2009 00:00:00 GMT