DSpace Collection: http://hdl.handle.net/2440/4285 Thu, 23 May 2013 15:51:42 GMT 2013-05-23T15:51:42Z Investigation of the substrate range of CYP199A4: modification of the partition between hydroxylation and desaturation activities by substrate and protein engineering http://hdl.handle.net/2440/76779 Title: Investigation of the substrate range of CYP199A4: modification of the partition between hydroxylation and desaturation activities by substrate and protein engineering Author: Bell, Stephen Graham; Zhou, Ruimin; Yang, Wen; Tan, Adrian B. H.; Gentleman, Alexander; Wong, Luet-Lok; Zhou, Weihong Sat, 31 Dec 2011 13:30:00 GMT http://hdl.handle.net/2440/76779 2011-12-31T13:30:00Z Molecular tweezers with freely rotating linker and porphyrin moieties http://hdl.handle.net/2440/76743 Title: Molecular tweezers with freely rotating linker and porphyrin moieties Author: Murphy, Rhys B.; Pham, Duc-Truc; Lincoln, Stephen Frederick; Johnston, Martin Ross Abstract: Molecular tweezers were synthesised by using a microwave accelerated alkene plus cyclobutane epoxide reaction between norbornyl appended porphyrin moieties and a diepoxide functionalised phenyl diimide spacer. The tweezers contain several rotational degrees of freedom; about the porphyrin with respect to the norbornyl linker, and between the two norbornyl backbone sections. The ability of Zn(super)II metallated tweezer 1 to complex 1,4-diazabicyclo[2.2.2]octane (DABCO) was studied by UV/Vis and ¹H NMR spectroscopy and multivariate global spectral analysis. The system was found to form a strong 1:1 intramolecular complex (1:DABCO) with an association constant of K₁₁ = 8.1 × 10⁷ M⁻¹, transforming to a 1:2 open complex [1:(DABCO)₂] with K₁₂ = 2.7 × 10⁹ M⁻² at high concentrations of DABCO. Mon, 31 Dec 2012 13:30:00 GMT http://hdl.handle.net/2440/76743 2012-12-31T13:30:00Z Tailoring an alien ferredoxin to support native-like P450 monooxygenase activity http://hdl.handle.net/2440/76722 Title: Tailoring an alien ferredoxin to support native-like P450 monooxygenase activity Author: Bell, Stephen Graham; McMillan, James H. C.; Yorke, Jake A.; Kavanagh, Emma; Johnson, Eachan O. D.; Wong, Luet-Lok Sat, 31 Dec 2011 13:30:00 GMT http://hdl.handle.net/2440/76722 2011-12-31T13:30:00Z A study on the diastereoselective synthesis of α-fluorinated β³-amino acids by α-fluorination http://hdl.handle.net/2440/75832 Title: A study on the diastereoselective synthesis of α-fluorinated β³-amino acids by α-fluorination Author: Peddie, Victoria; Abell, Andrew David Sat, 31 Dec 2011 13:30:00 GMT http://hdl.handle.net/2440/75832 2011-12-31T13:30:00Z