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https://hdl.handle.net/2440/3076
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Type: | Journal article |
Title: | A high-whey-protein diet reduces body weight gain and alters insulin sensitivity relative to red meat in Wistar rats |
Author: | Belobrajdic, D. McIntosh, G. Owens, J. |
Citation: | The Journal of Nutrition, 2004; 134(6):1454-1458 |
Publisher: | Amer Inst Nutrition |
Issue Date: | 2004 |
ISSN: | 0022-3166 1541-6100 |
Statement of Responsibility: | Damien P. Belobrajdic, Graeme H. McIntosh, and Julie A. Owens |
Abstract: | A high-protein diet can reduce body weight and increase insulin sensitivity, but whether the type of dietary protein affects these outcomes is unknown. We hypothesized that feeding insulin-resistant rats a high-protein diet (32%) containing whey protein concentrate (WPC) would reduce body weight and tissue lipid levels and increase insulin sensitivity more than a diet containing red meat (RM). Rats were fed a high-fat diet (300 g fat/kg diet) for 9 wk, then switched to a diet containing either 80 or 320 g protein/kg diet, provided by either WPC or RM, for 6 wk (n = 8). The rats were then killed after overnight food deprivation. High dietary protein reduced energy intake (P < 0.001) and visceral (P < 0.001), subcutaneous (P < 0.001), and carcass fat (P < 0.05). Increasing the dietary density of WPC, but not of RM, reduced body weight gain by 4% (P < 0.001). Dietary WPC also reduced plasma insulin concentration by 40% (P < 0.05) and increased insulin sensitivity, compared to RM (P < 0.05). These findings support the conclusions that a high-protein diet reduces energy intake and adiposity and that whey protein is more effective than red meat in reducing body weight gain and increasing insulin sensitivity. |
Keywords: | Whey protein red meat protein density weight gain insulin sensitivity |
Description: | © 2004 The American Society for Nutritional Sciences |
DOI: | 10.1093/jn/134.6.1454 |
Published version: | http://jn.nutrition.org/cgi/content/abstract/134/6/1454 |
Appears in Collections: | Aurora harvest 6 Molecular and Biomedical Science publications |
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