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https://hdl.handle.net/2440/43799
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Type: | Journal article |
Title: | Effects of progesterone on neurologic and morphologic outcome following diffuse traumatic brain injury in rats |
Author: | O'Connor, C. Cernak, I. Johnson, F. Vink, R. |
Citation: | Experimental Neurology, 2007; 205(1):145-153 |
Publisher: | Academic Press Inc Elsevier Science |
Issue Date: | 2007 |
ISSN: | 0014-4886 1090-2430 |
Statement of Responsibility: | Christine A. O'Connor, Ibolja Cernak, Felicity Johnson, and Robert Vink |
Abstract: | Previous studies have identified that progesterone may be neuroprotective following traumatic brain injury (TBI). However, most of these have utilized models of TBI that produce a focal lesion or a significant ischemic component, neither of which is necessarily present in diffuse TBI. The current study uses a model of diffuse TBI in rats to examine the effects of progesterone on morphological changes and functional outcome following TBI. Male and ovariectomized female rats were subject to severe impact-acceleration injury under halothane anesthesia. After injury, animals were given a physiological, subcutaneous dose of progesterone (1.67 mg/kg) or equal volume of vehicle (sesame oil) daily throughout a 9-day neurologic assessment period where functional outcome was assessed using the rotarod and Barnes maze tests. There was a similar post-injury performance of male and ovariectomized female animals. Post-injury administration of progesterone improved the motor and cognitive performance of ovariectomized and male animals compared to vehicle-treated controls. Morphological differences between these animals, such as dark cell change, caspase-3 and APP immunoreactivity, were also investigated. Progesterone-treated males showed comparatively less dead or dying neurons, and marked attenuation of caspase-3 immunoreactivity. Both ovariectomized female and male animals treated with progesterone showed a profound reduction in axonal injury (seen via diminished APP immunoreactivity) when compared to controls. We conclude that physiological concentrations of progesterone administered after diffuse TBI confers beneficial effects on morphologic and functional outcome in both ovariectomized female and male animals. |
Keywords: | hormone neurotrauma progesterone traumatic brain injury gender |
Description: | Available online 12 February 2007. |
Rights: | Copyright © 2007 Elsevier Inc. All rights reserved. |
DOI: | 10.1016/j.expneurol.2007.01.034 |
Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/622828/description#description |
Published version: | http://dx.doi.org/10.1016/j.expneurol.2007.01.034 |
Appears in Collections: | Aurora harvest Pathology publications |
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