Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/45416
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Type: Journal article
Title: A mouse model for assessing the impact of ingested nutrients on gastric emptying rate
Author: Symonds, E.
Butler, R.
Omari, T.
Citation: Clinical and Experimental Pharmacology and Physiology, 2007; 34(1-2):132-133
Publisher: Blackwell Publishing Asia
Issue Date: 2007
ISSN: 0305-1870
1440-1681
Statement of
Responsibility: 
Erin L Symonds, Ross Butler and Taher I Omari
Abstract: 1. The nutrient content of meals can affect the rate of gastric emptying. The aim of the present study was to assess whether the gastric emptying breath test could detect nutrient-induced delays in gastric emptying. 2. Following ingestion of a non-nutrient, carbohydrate- or lipid-containing liquid, mice were placed into chambers and breath samples were collected at intervals. Analysis of the rate of 13CO2 excretion allowed the calculation of gastric half-excretion time. 3. Gastric half-excretion time was significantly delayed by the incorporation of carbohydrate or lipid into the test liquid. 4. The present study has shown that the breath test is sensitive enough to detect changes induced by altering the nutrient and caloric content of test meals.
Keywords: Animals
Mice, Inbred C57BL
Mice
Carbon Dioxide
Water
Carbon Isotopes
Acetic Acid
Glucose
Fat Emulsions, Intravenous
Breath Tests
Models, Animal
Gastric Emptying
Food
Female
Description: The definitive version is available at www.blackwell-synergy.com
DOI: 10.1111/j.1440-1681.2007.04546.x
Published version: http://dx.doi.org/10.1111/j.1440-1681.2007.04546.x
Appears in Collections:Aurora harvest 6
Paediatrics publications

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