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https://hdl.handle.net/2440/45416
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Type: | Journal article |
Title: | A mouse model for assessing the impact of ingested nutrients on gastric emptying rate |
Author: | Symonds, E. Butler, R. Omari, T. |
Citation: | Clinical and Experimental Pharmacology and Physiology, 2007; 34(1-2):132-133 |
Publisher: | Blackwell Publishing Asia |
Issue Date: | 2007 |
ISSN: | 0305-1870 1440-1681 |
Statement of Responsibility: | Erin L Symonds, Ross Butler and Taher I Omari |
Abstract: | 1. The nutrient content of meals can affect the rate of gastric emptying. The aim of the present study was to assess whether the gastric emptying breath test could detect nutrient-induced delays in gastric emptying. 2. Following ingestion of a non-nutrient, carbohydrate- or lipid-containing liquid, mice were placed into chambers and breath samples were collected at intervals. Analysis of the rate of 13CO2 excretion allowed the calculation of gastric half-excretion time. 3. Gastric half-excretion time was significantly delayed by the incorporation of carbohydrate or lipid into the test liquid. 4. The present study has shown that the breath test is sensitive enough to detect changes induced by altering the nutrient and caloric content of test meals. |
Keywords: | Animals Mice, Inbred C57BL Mice Carbon Dioxide Water Carbon Isotopes Acetic Acid Glucose Fat Emulsions, Intravenous Breath Tests Models, Animal Gastric Emptying Food Female |
Description: | The definitive version is available at www.blackwell-synergy.com |
DOI: | 10.1111/j.1440-1681.2007.04546.x |
Published version: | http://dx.doi.org/10.1111/j.1440-1681.2007.04546.x |
Appears in Collections: | Aurora harvest 6 Paediatrics publications |
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