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Adelaide Research and Scholarship
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Schools and Disciplines
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School of Medicine
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Surgery
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Surgery (QEH) Publications
Permanent link to this item:
http://hdl.handle.net/2440/49010
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| Type: | Article |
| Title: | Nitric oxide from dysbiotic nitrate respiration of anaerobic bacteria initiates human ulcerative colitis |
| Author: | Roediger, W. E. W. |
| Citation: | Nitric Oxide-Biology and Chemistry, 2008; 19(Suppl 1):59-59 |
| Publisher: | Academic Press Inc Elsevier Science |
| Issue Date: | 2008 |
| ISSN: | 1089-8603 |
| School/Discipline: | Surgery |
Statement of
Responsibility: | William E.W. Roediger |
| Abstract: | Introduction: Factors initiating human ulcerative colitis (UC) are unknown. Dysbiosis of bacteria has been proposed to initiate UC but to date neither the nature of dysbiosis nor mucosal breakdown has been explained.
Method: To assess whether a dysbiosis of anaerobic nitrate respiration could explain the microscopic, biochemical and functional changes observed in colonocytes of ulcerative colitis by measuring the effect of NO on human colonocytes and observing colonic NO production.
Results: Anaerobic nitrate respiration yields nitrite, nitric oxide (NO) and nitrous oxide. Colonic bacteria produce NO and UC in remission has a higher luminal NO level than control cases. NO with sulphide but not NO alone impairs lipid and protein synthesis of epithelial cells explaining the membrane, tight junctional, ion channel and beta oxidation changes observed in colonocytes of UC. The observations complement therapeutic mechanisms of those probiotics, prebiotics and antibiotics useful in treating UC.
Conclusions: The prolonged production of bacterial NO with sulphide can explain the initiation and barrier breakdown which is central to the pathogenesis of UC. Therapies to alter bacterial nitrate respiration and NO production in pouchitis and human UC need to evolve. |
| Description: | Copyright © 2008 Published by Elsevier Inc. |
| RMID: | 0020084161 |
| DOI: | 10.1016/j.niox.2008.06.168 |
| Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/622926/description#description |
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| Appears in Collections: | Surgery (QEH) Publications
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