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Adelaide Research and Scholarship
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Schools and Disciplines
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School of Molecular and Biomedical Science
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Molecular and Biomedical Science Publications
Permanent link to this item:
http://hdl.handle.net/2440/52087
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| Type: | Article |
| Title: | Location, Location, Location! Monotremes Provide Unique Insights into the Evolution of Sex Chromosome Silencing in Mammals |
| Author: | Daish, Tasman James
Grutzner, Frank |
| Citation: | DNA and Cell Biology, 2009; 28 (2):91-100 |
| Publisher: | Mary Ann Liebert |
| Issue Date: | 2009 |
| ISSN: | 1044-5498 |
| School/Discipline: | School of Molecular and Biomedical Science |
Statement of
Responsibility: | Tasman Daish and Frank Grutzner |
| Abstract: | Platypus and echidnas are the only living representative of the egg-laying mammals that diverged 166 million
years ago from the mammalian lineage. Despite occupying a key spot in mammalian phylogeny, research on
monotremes has been limited by access to material and lack of molecular genetic resources. This has changed
recently, and the sequencing of the platypus genome has promoted monotremes into a generally accessible tool
in comparative genomics. The most extraordinary aspect of the monotreme genome is an amazingly complex sex
chromosomes system that shares extensive homology with bird sex chromosomes and no homology with sex
chromosomes of other mammals. This raises important questions about dosage compensation of the five pairs of
sex chromosomes in females and meiotic silencing in males, and we are only beginning to unravel possible
mechanisms and pathways that may be involved. The homology between monotreme and bird sex chromosomes
makes comparison between those species worthwhile, also as they provide a well-defined example where
the same sex chromosomes changed from female heterogamety (chicken) to male heterogamety (monotremes).
We summarize recent research on monotreme and chicken sex chromosomes and discuss possible mechanisms
that may contribute to sex chromosome silencing in monotremes. |
| Description: | Copyright © Mary Ann Liebert, Inc. |
| RMID: | 0020090166 |
| DOI: | 10.1089/dna.2008.0818 |
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| Appears in Collections: | Molecular and Biomedical Science Publications
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