Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/55011
Type: | Journal article |
Title: | Reduced accumulation of specific microRNAs in colorectal neoplasia |
Author: | Michael, M. O'Connor, S. Van Holst Pellekaan, N. Young, G. James, R. |
Citation: | Molecular Cancer Research, 2003; 1(12):882-891 |
Publisher: | Amer Assoc Cancer Research |
Issue Date: | 2003 |
ISSN: | 1541-7786 1557-3125 |
Statement of Responsibility: | Michael Z. Michael, Susan M. O’ Connor, Nicholas G. van Holst Pellekaan, Graeme P. Young and Robert J. James |
Abstract: | Short non-coding RNAs are known to regulate cellular processes including development, heterochromatin formation, and genomic stability in eukaryotes. Given the impact of these processes on cellular identity, a study was undertaken to investigate possible changes in microRNA (miRNA) levels during tumorigenesis. A total of 28 different miRNA sequences was identified in a colonic adenocarcinoma and normal mucosa, including 3 novel sequences and a further 7 that had previously been cloned only from mice. Human homologues of murine miRNA sequences, miR-143 and miR-145, consistently display reduced steady-state levels of the mature miRNA at the adenomatous and cancer stages of colorectal neoplasia. |
Keywords: | Intestinal Mucosa Cell Line, Tumor Humans Adenocarcinoma Colorectal Neoplasms MicroRNAs Blotting, Northern Gene Expression Regulation, Neoplastic Base Sequence Molecular Sequence Data |
Appears in Collections: | Aurora harvest Medicine publications |
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