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Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/59704

Type: Journal article
Title: Safety and efficacy of nontherapeutic male circumcision: A systematic review
Author: Perera, C.
Bridgewater, F.
Thavaneswaran, P.
Maddern, G.
Citation: Annals of Family Medicine, 2010; 8(1):64-72
Publisher: Annals of Family Medicine, Inc.
Issue Date: 2010
ISSN: 1544-1709
Statement of
Responsibility: 
Caryn L. Perera, Franklin H. G. Bridgewater, Prema Thavaneswaran and Guy J. Maddern
Abstract: PURPOSE: We wanted to assess the safety and efficacy of nontherapeutic male circumcision through a systematic review of the literature. METHODS We systematically searched The York Centre for Reviews and Disseminations, Cochrane Library, PubMed, and EMBASE databases for randomized controlled trials published between January 1997 and August 2008. Studies reporting on circumcision in an operative setting in males of any age with no contraindications to or medical indications for circumcision were eligible for inclusion. The main comparator was intact genitalia. From 73 retrieved studies, 8 randomized controlled trials were ultimately included for analysis. RESULTS: Severe complications were uncommon. Analgesia/anesthesia during circumcision was promoted. The prevalence of self-reported genital ulcers was significantly lower in circumcised men than uncircumcised men (3.1% vs 5.8%; prevalence risk ratio 0.53; 95% confidence interval [CI], 0.43-0.64; P <.001). Circumcised sub-Saharan African men were at significantly lower risk of acquiring human immunodeficiency virus/acquired immune deficiency syndrome than were uncircumcised men (random effects odds ratio = 0.44, 95% CI, 0.32-0.59; P <.001). The evidence suggests that adult circumcision does not affect sexual satisfaction and function. CONCLUSIONS: Strong evidence suggests circumcision can prevent human immunodeficiency virus/acquired immune deficiency syndrome acquisition in sub- Saharan African men. These findings remain uncertain in men residing in other countries. The role of adult nontherapeutic male circumcision in preventing sexually transmitted infections, urinary tract infections, and penile cancer remains unclear. Current evidence fails to recommend widespread neonatal circumcision for these purposes.
Keywords: Circumcision, male; sexually transmitted diseases; HIV; acquired immunodeficiency syndrome; penile cancer; urinary tract infections; prophylactic procedures
Rights: © 2010 Annals of Family Medicine, Inc.
RMID: 0020100199
DOI: 10.1370/afm.1073
Appears in Collections:Surgery publications
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