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https://hdl.handle.net/2440/61492
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Type: | Journal article |
Title: | Discordant effects of vitamin D deficiency in trabecular and cortical bone architecture and strength in growing rodents |
Author: | Lee, A. Anderson, P. Sawyer, R. Moore, A. Forwood, M. Steck, R. Morris, H. O'Loughlin, P. |
Citation: | The Journal of Steroid Biochemistry and Molecular Biology, 2010; 121(1-2):284-287 |
Publisher: | Pergamon-Elsevier Science Ltd |
Issue Date: | 2010 |
ISSN: | 0960-0760 1879-1220 |
Statement of Responsibility: | Alice M.C. Lee, Paul H. Anderson, Rebecca K. Sawyer, Alison J. Moore, Mark R. Forwood, Roland Steck, Howard A. Morris and Peter D. O’Loughlin |
Abstract: | We have previously shown that vitamin D deficiency in young male rats results in significant reduction in femoral trabecular bone volume (BV/TV). However, the effects of vitamin D deficiency and its impact on other relevant skeletal sites remain unclear. Ten week old male Sprague-Dawley rats were fed various levels of vitamin D3 (2, 4, 8, and 12 IU/day) with standard Ca (0.4%) until 30 weeks of age and achieved stable serum 25-hydroxyvitamin D3 (25D) levels between 16 and 117 nmol/L. At time of death, femora, L2 vertebrae and tibiae were processed for bone histomorphometric analyses and tibial cortical strength by 3-point mechanical testing. A significant association between serum 25D and trabecular bone occurred for both the distal femoral metaphysis (R2=0.34, P<0.05) and L2 vertebrae (R2=0.24, P<0.05). Tibia mid-shaft cortical bone was not, however, changed in terms of total volume, periosteal surface or endosteal surface as a function of vitamin D status. Furthermore, no changes to mechanical and intrinsic properties of the cortices were observed. We conclude that cortical bone is maintained under conditions of vitamin D deficiency in preference to cancellous bone in young growing rats. |
Keywords: | Serum 25D Cortical bone volume Strength Young’s modulus Ultimate load to failure |
Rights: | © 2010 Published by Elsevier Ltd. |
DOI: | 10.1016/j.jsbmb.2010.04.004 |
Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/333/description#description |
Published version: | http://dx.doi.org/10.1016/j.jsbmb.2010.04.004 |
Appears in Collections: | Aurora harvest 5 Pharmacology publications |
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