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Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/64550

Type: Book
Title: Beneficial effects of perhexiline in cardiovascular disease states
Author: Chirkov, Yuliy
Sverdlov, Aaron Leonid
Horowitz, John David
Publisher: NOVA Science Publishers
Issue Date: 2010
Series/Report no.: Cardiology Research and Clinical Developments
ISBN: 9781616689773
Cover art
School/Discipline: School of Medicine : Medicine
Statement of
Responsibility: 
Yuliy Y. Chirkov, Aaron L. Sverdlov, and John D. Horowitz
Abstract: Perhexiline, 2-(2,2-dicyclohexylethyl)piperidine, was originally developed as a prophylactic anti-anginal drug in the late 1960s. It was initially a popular and effective treatment for angina, having the almost unique property compared to other agents available at that time, of not inducing reductions in blood pressure or heart rate. Despite the initial success, its use diminished markedly due to the occurrence during long-term therapy of poorly understood side effects (neurotoxicity and hepatotoxicity), which later were shown to be associated with high plasma concentrations of perhexiline, occurring in patients with relatively slow hepatic metabolism of the drug. However, therapeutic plasma monitoring and associated dose adjustments have led to perhexiline's reintroduction into clinical practice. This new book discusses the benefits of perhexiline in the treatment of cardiovascular disease.
Rights: Copyright status unknown
Description (link): http://trove.nla.gov.au/work/37252295
Appears in Collections:Medicine publications

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