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https://hdl.handle.net/2440/65737
Type: | Journal article |
Title: | Amygdala reactivity to masked negative faces is associated with automatic judgmental bias in major depression: a 3 T fMRI study |
Author: | Dannlowski, Udo Ohrmann, Patricia Bauer, Jochen Kugel, Harald Arolt, Volker Heindel, Walter Kersting, Anette Baune, Bernhard Theodor Suslow, Thomas |
Citation: | Journal of Psychiatry & Neuroscience, 2007; 32(6):423-429 |
Publisher: | Canadian Medical Association |
Issue Date: | 2007 |
ISSN: | 1180-4882 |
School/Discipline: | School of Medicine : Psychiatry |
Statement of Responsibility: | Udo Dannlowski, Patricia Ohrmann, Jochen Bauer, Harald Kugel, Volker Arolt, Walter Heindel, Anette Kersting, Bernhard T. Baune, Thomas Suslow |
Abstract: | Objective: In a previous study, we demonstrated that amygdala reactivity to masked negative facial emotions predicts negative judgmental bias in healthy subjects. In the present study, we extended the paradigm to a sample of 35 inpatients suffering from depression to investigate the effect of amygdala reactivity on automatic negative judgmental bias and clinical characteristics in depression. Methods: Amygdala activity was recorded in response to masked displays of angry, sad and happy facial expressions by means of functional magnetic resonance imaging at 3 T. In a subsequent experiment, the patients performed an affective priming task that characterizes automatic emotion processing by investigating the biasing effect of subliminally presented emotional faces on evaluative ratings to subsequently presented neutral stimuli. Results: Significant associations between (right) amygdala reactivity and automatic negative judgmental bias were replicated in our patient sample (r = –0.59, p < 0.001). Further, negatively biased evaluative processing was associated with severity and longer course of illness (r = –0.57, p = 0.001). Conclusion: Amygdala hyperactivity is a neural substrate of negatively biased automatic emotion processing that could be a determinant for a more severe disease course. |
Keywords: | depressive disorder, major; magnetic resonance imaging, functional; amygdala; emotion. |
Rights: | © 2007 Canadian Medical Association |
Published version: | http://www.cma.ca/index.php/ci_id/54349/la_id/1.htm |
Appears in Collections: | Psychiatry publications |
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