Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/68672
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Epidermolysis bullosa acquisita in a great Dane |
Author: | Hill, P. Boyer, P. Lau, P. Rybnicek, J. Hargreaves, J. Olivry, F. |
Citation: | Journal of Small Animal Practice, 2008; 49(2):89-94 |
Publisher: | British Veterinary Assoc |
Issue Date: | 2008 |
ISSN: | 0022-4510 1748-5827 |
Statement of Responsibility: | P. B. Hill, P. Boyer, P. Lau, J. Rybnicek, J. Hargreaves and T. Olivry |
Abstract: | Autoimmune subepidermal blistering diseases in dogs were all classified as bullous pemphigoid until 1998. Since then, refinements in reagents and immunological techniques have allowed diseases which are histologically similar but which have a different molecular pathogenesis to be described. This report describes the first case of one such disease, epidermolysis bullosa acquisita, to be documented in the UK. The dog presented with a severe blistering and ulcerative disease affecting the oral cavity, pinnae and distal limbs. The diagnosis was confirmed by histopathology and direct and indirect immunofluorescent demonstration of immunoglobulin G reactivity to basement membrane antigens. Treatment with glucocorticoids, azathioprine, colchicine and an intravenous infusion of immunoglobulins resulted in complete resolution. The drugs were discontinued 12 months after the start of treatment and the dog remained in remission. |
Keywords: | Epidermis Animals Dogs Epidermolysis Bullosa Acquisita Dog Diseases Colchicine Azathioprine Immunoglobulins Immunoglobulin G Immunosuppressive Agents Glucocorticoids Fluorescent Antibody Technique Remission Induction Female |
Rights: | © 2007 British Small Animal Veterinary Association |
DOI: | 10.1111/j.1748-5827.2007.00419.x |
Published version: | http://dx.doi.org/10.1111/j.1748-5827.2007.00419.x |
Appears in Collections: | Animal and Veterinary Sciences publications Aurora harvest 5 |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.