Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/72057
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Premixed, injectable PLA-modified calcium deficient apatite biocement(cd-AB)with washout resistance |
Author: | Wu, F. Ngothai, Y. Wei, J. Liu, C. O'Neill, B. Wu, Y. |
Citation: | Colloids and Surfaces B: Biointerfaces, 2012; 92:113-120 |
Publisher: | Elsevier Science BV |
Issue Date: | 2012 |
ISSN: | 0927-7765 1873-4367 |
Statement of Responsibility: | Fan Wu, Yung Ngothai, Jie Wei, Changsheng Liu, Brian O’Neill and Yuequn Wu |
Abstract: | By using a non-aqueous solution as the mixing liquid, the washout resistance of the calcium deficient apatite biocement (cd-AB) was significantly improved, over that of the conventional method of using cd-AB with water as the liquid phase. In this study, premixed and injectable cd-AB was prepared, which had the advantage of being stable in the syringe and hardens only after being delivered to the defect area. The cd-AB powder with a Ca/P ratio of 1.5 consists of a mixture of tetracalcium phosphate (TTCP) and dicalcium phosphate anhydrous (DCPA). A solution of polylactide (PLA) in N-methyl-2-pyrrolidone (NMP) was used as the liquid phase of the premixed cd-AB. The premixed cd-AB paste injected into an aqueous environment exhibited excellent washout resistance. The premixed cd-AB had longer setting time and lower compressive strength than conventional cd-AB. The hydration products of premixed cd-AB were a mixture of calcium deficient hydroxyapatite (cd-HA) and PLA. In vitro Tris-HCl immersion tests demonstrated that the premixed cd-AB could be degradable. The results revealed that the premixed cd-AB was cytocompatible and had no adverse effects on the attachment and proliferation of MG-63 osteoblast-like cells in vitro. The most distinct advantages of premixed and injectable PLA-modified cd-AB were its excellent washout resistance and in vitro degradability, suggesting that it may be a promising candidate for bone repair. |
Keywords: | Cell Line Osteoblasts Humans Apatites Calcium Bone Cements Polyesters Microscopy, Electron, Scanning X-Ray Diffraction Injections Materials Testing Compressive Strength Hardness Time Factors |
Rights: | © 2011 Elsevier B.V. All rights reserved. |
DOI: | 10.1016/j.colsurfb.2011.11.037 |
Published version: | http://dx.doi.org/10.1016/j.colsurfb.2011.11.037 |
Appears in Collections: | Aurora harvest Chemical Engineering publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.