Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/72057
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Type: Journal article
Title: Premixed, injectable PLA-modified calcium deficient apatite biocement(cd-AB)with washout resistance
Author: Wu, F.
Ngothai, Y.
Wei, J.
Liu, C.
O'Neill, B.
Wu, Y.
Citation: Colloids and Surfaces B: Biointerfaces, 2012; 92:113-120
Publisher: Elsevier Science BV
Issue Date: 2012
ISSN: 0927-7765
1873-4367
Statement of
Responsibility: 
Fan Wu, Yung Ngothai, Jie Wei, Changsheng Liu, Brian O’Neill and Yuequn Wu
Abstract: By using a non-aqueous solution as the mixing liquid, the washout resistance of the calcium deficient apatite biocement (cd-AB) was significantly improved, over that of the conventional method of using cd-AB with water as the liquid phase. In this study, premixed and injectable cd-AB was prepared, which had the advantage of being stable in the syringe and hardens only after being delivered to the defect area. The cd-AB powder with a Ca/P ratio of 1.5 consists of a mixture of tetracalcium phosphate (TTCP) and dicalcium phosphate anhydrous (DCPA). A solution of polylactide (PLA) in N-methyl-2-pyrrolidone (NMP) was used as the liquid phase of the premixed cd-AB. The premixed cd-AB paste injected into an aqueous environment exhibited excellent washout resistance. The premixed cd-AB had longer setting time and lower compressive strength than conventional cd-AB. The hydration products of premixed cd-AB were a mixture of calcium deficient hydroxyapatite (cd-HA) and PLA. In vitro Tris-HCl immersion tests demonstrated that the premixed cd-AB could be degradable. The results revealed that the premixed cd-AB was cytocompatible and had no adverse effects on the attachment and proliferation of MG-63 osteoblast-like cells in vitro. The most distinct advantages of premixed and injectable PLA-modified cd-AB were its excellent washout resistance and in vitro degradability, suggesting that it may be a promising candidate for bone repair.
Keywords: Cell Line
Osteoblasts
Humans
Apatites
Calcium
Bone Cements
Polyesters
Microscopy, Electron, Scanning
X-Ray Diffraction
Injections
Materials Testing
Compressive Strength
Hardness
Time Factors
Rights: © 2011 Elsevier B.V. All rights reserved.
DOI: 10.1016/j.colsurfb.2011.11.037
Published version: http://dx.doi.org/10.1016/j.colsurfb.2011.11.037
Appears in Collections:Aurora harvest
Chemical Engineering publications

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