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Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/72819

Type: Journal article
Title: Comparison of the effects of xylazine bolus versus medetomidine constant rate infusion on cardiopulmonary function and depth of anesthesia in horses anesthetized with isoflurane
Author: Creighton, Catherine
Lemke, Kip A.
Lamont, Leigh A.
Horney, Barbara S.
Riley, Christopher Bruce
Citation: Journal of the American Veterinary Medical Association, 2012; 240(8):991-997
Publisher: Amer Veterinary Medical Assoc
Issue Date: 2012
ISSN: 0003-1488
School/Discipline: School of Animal and Veterinary Sciences
Statement of
Responsibility: 
Catherine M. Creighton, Kip A. Lemke, Leigh A. Lamont, Barbara S. Horney, Christopher B. Riley
Abstract: Objective—To compare the effects of xylazine bolus versus medetomidine constant rate infusion (MCRI) on cardiopulmonary function and depth of anesthesia in dorsally recumbent, spontaneously breathing, isoflurane-anesthetized horses. Design—Prospective, randomized crossover study. Animals—10 healthy adult Standardbreds. Procedures—Horses were premedicated with xylazine or medetomidine IV. Anesthesia was induced with diazepam and ketamine and maintained with isoflurane for 150 minutes. For the xylazine treatment, end-tidal isoflurane concentration was maintained at 1.7%, and xylazine (0.2 mg/kg [0.09 mg/lb], IV) was administered as a bolus at the end of anesthesia. For the MCRI treatment, end-tidal isoflurane concentration was maintained at 1.4%, and medetomidine (0.005 mg/kg/h [0.0023 mg/lb/h], IV) was infused throughout anesthesia. Physiologic data (ie, heart rate, respiratory rate, rectal temperature, bispectral index, and electromyographic values) were compared between treatments with xylazine bolus versus MCRI. Results—Heart rate was lower, but mean arterial blood pressure was higher from 20 to 40 minutes with MCRI treatment, compared with conventional treatment with xylazine. Respiratory rate and rectal temperature were greater with MCRI treatment. Bispectral index was lower with MCRI treatment from 80 to 150 minutes, and electromyographic values were lower with MCRI treatment from 30 to 150 minutes. Conclusions and Clinical Relevance—In isoflurane-anesthetized horses, premedication with medetomidine followed by administration of medetomidine as a constant rate infusion resulted in decreased heart rate, higher arterial blood pressure from 20 through 40 minutes after induction of anesthesia, and better preserved body temperature, compared with conventional treatment with xylazine. Greater depth of anesthesia and muscle relaxation were seen with MCRI treatment, despite the lower isoflurane concentration.
Rights: Copyright status unknown
RMID: 0020118331
DOI: 10.2460/javma.240.8.991
Appears in Collections:Animal and Veterinary Sciences publications
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