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Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/73423

Type: Journal article
Title: A 25-year longitudinal evaluation of gastric emptying in diabetes
Author: Chang, Jessica Lee Sing
Russo, Antonietta
Bound, Michelle
Rayner, Christopher Keith
Jones, Karen Louise
Horowitz, Michael
Citation: Diabetes Care, 2012; 35(12):2594-2596
Publisher: American Diabetes Association
Issue Date: 2012
ISSN: 0149-5992
School/Discipline: Medicine
Statement of
Responsibility: 
Jessica Chang, Antonietta Russo, Michelle Bound, Christopher K. Rayner, Karen L. Jones and Michael Horowitz
Abstract: OBJECTIVE: To evaluate the natural history of gastric emptying in diabetes. RESEARCH DESIGN AND METHODS: Thirteen patients with diabetes (12, type 1; 1, type 2) had measurements of gastric emptying, blood glucose levels, glycated hemoglobin, upper gastrointestinal symptoms, and autonomic nerve function at baseline and after 24.7 ± 1.5 years. RESULTS: There was no change in gastric emptying of either solids (% retention at 100 min) (baseline 58.5 ± 5% vs. follow-up 51.9 ± 8%; P = 0.35) or liquids (50% emptying time) (baseline 29.8 ± 3 min vs. follow-up 34.3 ± 6 min; P = 0.37). Gastric emptying of solid at follow-up was related to emptying at baseline (r = 0.56, P < 0.05). At follow-up, blood glucose concentrations were lower (P = 0.006), autonomic function deteriorated (P = 0.03), and gastrointestinal symptoms remained unchanged (P = 0.17). CONCLUSIONS: In unselected patients with diabetes, gastric emptying appears remarkably stable over 25 years.
Rights: © 2012 by the American Diabetes Association
RMID: 0020121875
DOI: 10.2337/dc12-0028
Appears in Collections:Medicine publications
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