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Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/73460

Type: Journal article
Title: Repeat antenatal glucocorticoids for women at risk of preterm birth: a Cochrane Systematic Review
Author: McKinlay, Christopher J. D.
Crowther, Caroline Anne
Middleton, Philippa Fairfax
Harding, Jane E.
Citation: American Journal of Obstetrics and Gynecology, 2012; 206(3):187-194
Publisher: Mosby
Issue Date: 2012
ISSN: 0002-9378
School/Discipline: School of Paediatrics and Reproductive Health : Obstetrics and Gynaecology
Statement of
Responsibility: 
Christopher J. D. McKinlay, Caroline A. Crowther, Philippa Middleton and Jane E. Harding
Abstract: Administration of antenatal glucocorticoids to women at risk of preterm birth has major benefits for infants but the use of repeat dose(s) is controversial. We performed a systematic review of randomized trials, using standard Cochrane methodology, to assess the effectiveness and safety of 1 or more repeat doses given to women at risk of preterm birth 7 or more days after an initial course. Ten trials were included involving over 4730 women and 5700 infants. Treatment with repeat dose(s) compared with no repeat treatment reduced the risk of respiratory distress syndrome (risk ratio, 0.83; 95% confidence interval, 0.75–0.91) and serious neonatal morbidity (risk ratio, 0.84; 95% confidence interval, 0.75–0.94). At 2- to 3-year follow-up (4 trials, 4170 children), there was no evidence of either significant benefit or harm. Repeat doses of glucocorticoids should be considered in women at risk of preterm birth 7 or more days after an initial course, in view of the neonatal benefits.
Keywords: Prenatal corticosteroids; repeat antenatal glucocorticoids; respiratory distress syndrome; systematic review
Description: Presented at the 15th Annual Congress of the Perinatal Society of Australia and New Zealand, Hobart, Tasmania, Australia, April 10-13, 2011.
This review is an abridged version of a Cochrane Review previously published in the Cochrane Database of Systematic Reviews 2011, Issue 6, doi: 10.1002/14651858.CD003935
Rights: Copyright © 2012 Mosby, Inc. All rights reserved.
RMID: 0020116836
DOI: 10.1016/j.ajog.2011.07.042
Appears in Collections:Obstetrics and Gynaecology Publications
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