University of Adelaide Library

Adelaide Research and Scholarship : Schools and Disciplines : School of Animal and Veterinary Sciences : Animal and Veterinary Sciences publications

Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/73569

Type: Journal article
Title: Comparative approach to understanding traumatic injury in the immature, postnatal brain of domestic animals
Author: Finnie, J.
Citation: Australian Veterinary Journal, 2012; 90(8):301-307
Publisher: Australian Veterinary Assn
Issue Date: 2012
ISSN: 0005-0423
1751-0813
Statement of
Responsibility: 
J.W. Finnie
Abstract: Traumatic brain injury (TBI) is a frequent occurrence in veterinary medicine, but the mechanisms leading to brain damage after a head impact are incompletely understood, particularly in the postnatal immature and still developing nervous system. This paper reviews neurotrauma studies, largely in paediatric humans and experimental animal models, in order to outline the pathophysiological and biomechanical events likely to be operative in head trauma involving domestic animal species in the postnatal period, as there is almost no other information available in the veterinary literature. Predicting the outcome of TBI is particularly difficult at this developmental time, in large part because recovery is influenced by the stage of brain maturation and neuroplasticity. An important part of the clinical management of TBI is the differentiation of primary brain damage, which occurs at the moment of head impact and is largely refractory to treatment, from the cascade of secondary events, which evolve over time and are potentially preventable and amenable to therapeutic intervention. An understanding of the causes and consequences of secondary brain damage such as hypoxia–ischaemia, brain swelling, elevated intracranial pressure, and infection is critical to limiting the resulting brain injury.
Keywords: Injury mechanisms; paediatrics; postnatal brain; neurology; traumatic brain injury
Rights: © 2012 The Author. Australian Veterinary Journal © 2012 Australian Veterinary Association
RMID: 0020121045
DOI: 10.1111/j.1751-0813.2012.00955.x
Appears in Collections:Animal and Veterinary Sciences publications
View citing articles in: Web of Science
Google Scholar
Scopus

There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

© 2008 The University of Adelaide
library@adelaide.edu.au
CRICOS Provider Number 00123M
Service Charter | Copyright | Privacy | Disclaimer