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Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/73667

Type: Journal article
Title: Postnatal development of metabolic flexibility and enhanced oxidative capacity after prenatal undernutrition
Author: Norman, Amy M.
Miles-Chan, Jennifer L.
Thompson, Nichola M.
Breier, Bernhard H.
Huber, Korinna
Citation: Reproductive Sciences, 2012; 19(6):607-614
Publisher: Sage Publications
Issue Date: 2012
ISSN: 1933-7191
School/Discipline: School of Medical Sciences
Statement of
Responsibility: 
Amy M. Norman, Jennifer L. Miles-Chan, Nichola M. Thompson, Bernhard H. Breier and Korinna Huber
Abstract: Metabolic flexibility is the body’s ability to adapt to changing energy demand and nutrient supply. Maternal undernutrition causes growth restriction at birth and subsequent obesity development. Intriguingly, metabolic flexibility is maintained due to adaptations of muscle tissue. The aim of the present study was to investigate developmental pathways of these adaptive changes. Wistar rats received standard chow at either ad libitum (AD) or 30% of ad libitum intake (UN) throughout pregnancy. At all ages, metabolic status indicated similar insulin sensitivity in AD and UN offspring despite the development of adiposity in UN offspring at weaning. Type IIA fiber size was reduced in soleus muscle of UN offspring at weaning and they had a higher percentage of type I fibers in adulthood with a concomitantly higher oxidative capacity. Plasticity of muscle was present during the postnatal period and proposes novel pathways for the dynamic development of metabolic flexibility throughout postnatal life.
Keywords: Prenatal nutrition; postnatal development; muscle structure; metabolic flexibility
Rights: © The Author(s) 2012
RMID: 0020120477
DOI: 10.1177/1933719111428519
Appears in Collections:Medical Sciences publications
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