Adelaide Research and Scholarship
Schools and Disciplines
School of Medical Sciences
Medical Sciences publications
Please use this identifier to cite or link to this item:
|Type: ||Journal article|
|Title: ||Postnatal development of metabolic flexibility and enhanced oxidative capacity after prenatal undernutrition|
|Author: ||Norman, Amy M.|
Miles-Chan, Jennifer L.
Thompson, Nichola M.
Breier, Bernhard H.
|Citation: ||Reproductive Sciences, 2012; 19(6):607-614|
|Publisher: ||Sage Publications|
|Issue Date: ||2012|
|School/Discipline: ||School of Medical Sciences|
|Amy M. Norman, Jennifer L. Miles-Chan, Nichola M. Thompson, Bernhard H. Breier and Korinna Huber|
|Abstract: ||Metabolic flexibility is the body’s ability to adapt to changing energy demand and nutrient supply. Maternal undernutrition causes growth restriction at birth and subsequent obesity development. Intriguingly, metabolic flexibility is maintained due to adaptations of muscle tissue. The aim of the present study was to investigate developmental pathways of these adaptive changes. Wistar rats received standard chow at either ad libitum (AD) or 30% of ad libitum intake (UN) throughout pregnancy. At all ages, metabolic status indicated similar insulin sensitivity in AD and UN offspring despite the development of adiposity in UN offspring at weaning. Type IIA fiber size was reduced in soleus muscle of UN offspring at weaning and they had a higher percentage of type I fibers in adulthood with a concomitantly higher oxidative capacity. Plasticity of muscle was present during the postnatal period and proposes novel pathways for the dynamic development of metabolic flexibility throughout postnatal life.|
|Keywords: ||Prenatal nutrition; postnatal development; muscle structure; metabolic flexibility|
|Rights: ||© The Author(s) 2012|
|Appears in Collections:||Medical Sciences publications|
|View citing articles in: ||Web of Science|
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.