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Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/73963

Type: Journal article
Title: The value of the metabolic syndrome concept in elderly adults: is it worth less than the sum of its parts?
Author: Samaras, Katherine
Crawford, John
Baune, Bernhard Theodor
Campbell, Lesley V.
Smith, Evelyn
Lux, Ora
Brodaty, Henry
Trollor, Julian N.
Sachdev, Perminder S.
Citation: Journal of the American Geriatrics Society, 2012; 60(9):1734-1741
Publisher: Blackwell
Issue Date: 2012
ISSN: 0002-8614
School/Discipline: Psychiatry
Statement of
Responsibility: 
Katherine Samaras, John Crawford, Bernard T. Baune, Lesley V. Campbell, Evelyn Smith, Ora Lux, Henry Brodaty, Julian N. Trollor and Perminder Sachdev
Abstract: OBJECTIVES: To determine whether the metabolic syndrome (MetS) or its components were more closely associated with disease states and inflammation in elderly adults. DESIGN: Sydney Memory and Ageing Study. Crosssectional, observational cohort. SETTING: Population-derived, community-dwelling elderly adults. PARTICIPANTS: Nine hundred thirty individuals aged 70 to 90. MEASUREMENTS: Age-and sex-adjusted odds ratios(ORs)for disease states; fasting circulating inflammatory markers and oxidative metabolism byproducts. RESULTS: MetS was associated with diabetes mellitus (OR = 4.1, P <.001) and bowel cancer (OR = 9.1, P = .03) but not in analyses that controlled for component conditions. Models containing component conditions had the strongest associations with heart disease. Disease associations were improved after addition of component conditions to the MetS model. The reverse did not hold: disease associations were not improved when MetS was added to the components model. Low high-density lipoprotein cholesterol (HDL-C) was independently associated with myocardial infarction (OR = 2.32) and angina pectoris (OR = 2.59) (both P <.008). Waist circumference was independently associated with cancer (OR = 1.82, P =.008). Although MetS was associated with higher C-reactive protein, vascular cell adhesion molecule, interleukin-6, amyloid A, homocysteine, and malondialdehyde, it explained less than half of the variance of models containing its components. CONCLUSION: The observation that MetS is associated with disease states and markers of circulating inflammation in the elderly is explained mainly by abdominal obesity and low HDL-C. Longitudinal data will further clarify these cross-sectional findings that MetS appears to be less than the sum of its parts in elderly adults.
Keywords: Metabolic syndrome; diabetes mellitus; obesity; lipids; inflammation
Rights: © 2012, Copyright the Authors Journal compilation © 2012, The American Geriatrics Society
RMID: 0020122115
DOI: 10.1111/j.1532-5415.2012.04105.x
Appears in Collections:Psychiatry publications
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