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https://hdl.handle.net/2440/76229
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Type: | Journal article |
Title: | Stressful life events and the serotonin transporter gene (5-HTT) in recurrent clinical depression |
Author: | Fisher, H. Cohen-Woods, S. Hosang, G. Uher, R. Powell-Smith, G. Keers, R. Tropeano, M. Korszun, A. Jones, L. Jones, I. Owen, M. Craddock, N. Craig, I. Farmer, A. McGuffin, P. |
Citation: | Journal of Affective Disorders, 2012; 136(1-2):189-193 |
Publisher: | Elsevier Science BV |
Issue Date: | 2012 |
ISSN: | 0165-0327 1573-2517 |
Statement of Responsibility: | Helen L. Fisher, Sarah Cohen-Woods, Georgina M. Hosang, Rudolf Uher, Georgia Powell-Smith, Robert Keers, Maria Tropeano, Ania Korszun, Lisa Jones, Ian Jones, Mike Owen, Nick Craddock, Ian W. Craig, Anne E. Farmer, Peter McGuffin |
Abstract: | <h4>Background</h4>An interaction between recent stressful life events (SLEs) and a serotonin transporter promoter polymorphism (5-HTTLPR) in depression has been inconsistently reported. Some of this variability may be due to a previous focus on sub-clinical depression, inclusion of individuals at the lower or upper ends of the age-span, or assumptions concerning the degree of dominance of the low expressing allele. Therefore, a large sample of patients with recurrent clinically diagnosed depression and controls screened for absence of depression was utilised to examine the moderating effect of each 5-HTTLPR genetic model on the association between SLEs and severe depressive episodes.<h4>Method</h4>A sample of 1236 recurrent unipolar depression cases and 598 age-matched, never psychiatrically ill controls completed the List of Threatening Experiences Questionnaire to assess the number of SLEs experienced in the 6 months prior to the most severe depressive episode (cases) or interview (controls). DNA extracted from blood or cheek swabs was genotyped for the short (s) and long (l) alleles of 5-HTTLPR.<h4>Results</h4>A greater number of SLEs were reported by cases than controls and this held across all genotypic groups. There was no main effect of 5-HTTLPR on depression and no evidence of interaction between total SLEs and any of the 5-HTTLPR genetic models. The results were the same for men and women.<h4>Limitations</h4>Utilisation of retrospective self-reported SLEs may have reduced the accuracy of the findings and the cross-sectional design prevents causal inference.<h4>Conclusions</h4>This study failed to find evidence of gene-environment interplay in recurrent clinical depression. |
Keywords: | Stressful life events Unipolar depression Recurrent Gene–environment interaction 5-HTTLPR |
Rights: | Copyright © 2011 Elsevier B.V. All rights reserved. |
DOI: | 10.1016/j.jad.2011.09.016 |
Published version: | http://dx.doi.org/10.1016/j.jad.2011.09.016 |
Appears in Collections: | Aurora harvest Psychiatry publications |
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