Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/81869
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Type: | Journal article |
Title: | Impairment of pneumococcal antigen specific isotype-switched IgG memory B-cell immunity in HIV infected Malawian adults |
Author: | Iwajomo, O. Finn, A. Ogunniyi, A. Williams, N. Heyderman, R. |
Citation: | PLoS One, 2013; 8(11):1-7 |
Publisher: | Public Library of Science |
Issue Date: | 2013 |
ISSN: | 1932-6203 1932-6203 |
Editor: | Gray, C.M. |
Statement of Responsibility: | Oluwadamilola H. Iwajomo, Adam Finn, Abiodun D. Ogunniyi, Neil A. Williams, Robert S. Heyderman |
Abstract: | Pneumococcal disease is associated with a particularly high morbidity and mortality amongst adults in HIV endemic countries. Our previous findings implicating a B-cell defect in HIV-infected children from the same population led us to comprehensively characterize B-cell subsets in minimally symptomatic HIV-infected Malawian adults and investigate the isotype-switched IgG memory B-cell immune response to the pneumococcus. We show that similar to vertically acquired HIV-infected Malawian children, horizontally acquired HIV infection in these adults is associated with IgM memory B-cell (CD19+ CD27+ IgM+ IgD+) depletion, B-cell activation and impairment of specific IgG B-cell memory to a range of pneumococcal proteins. Our data suggest that HIV infection affects both T-cell independent and T-cell dependent B-cell maturation, potentially leading to impairment of humoral responses to extracellular pathogens such as the pneumococcus, and thus leaving this population susceptible to invasive disease. |
Keywords: | B-Lymphocyte Subsets Humans Streptococcus pneumoniae HIV Pneumonia, Pneumococcal HIV Infections Immunoglobulin G Immunoglobulin M Antigens, Bacterial Lymphocyte Depletion Case-Control Studies Lymphocyte Activation Immunoglobulin Class Switching Immunologic Memory Adult Malawi Female Male |
Rights: | © 2013 Iwajomo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
DOI: | 10.1371/journal.pone.0078592 |
Published version: | http://dx.doi.org/10.1371/journal.pone.0078592 |
Appears in Collections: | Aurora harvest 4 Molecular and Biomedical Science publications |
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hdl_81869.pdf | Published version | 585.17 kB | Adobe PDF | View/Open |
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