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https://hdl.handle.net/2440/83023
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Type: | Journal article |
Title: | Interactions between adenosine and dopamine receptor antagonists with different selectivity profiles: effects on locomotor activity |
Author: | Collins-Praino, L. Galtieri, D. Collins, P. Jones, S. Port, R. Paul, N. Hockemeyer, J. Muller, C. Salamone, J. |
Citation: | Behavioural Brain Research, 2010; 211(25):148-155 |
Publisher: | Elsevier Science BV |
Issue Date: | 2010 |
ISSN: | 0166-4328 1872-7549 |
Statement of Responsibility: | Lyndsey E. Collins, Daniel J. Galtieri, Patricia Collins, Shawnet K. Jones, Russell G. Port, Nicholas E. Paul, Jörg Hockemeyer, Christa E. Müller, John D. Salamone |
Abstract: | Forebrain dopamine (DA) is a critical component of the brain circuitry regulating behavioral activation. Adenosine A(2A) antagonists reverse many of the behavioral effects of DA antagonists, and A(2A) receptors are co-localized with D(2) receptors on striatal medium spiny neurons. The present work was undertaken to determine if the ability of an A(2A) antagonist, a non-selective adenosine antagonist, or an A(1) antagonist to reverse the locomotor effects of DA blockade in rats differed depending upon whether D(1) or D(2) family receptors were being antagonized. The adenosine antagonists MSX-3, caffeine, DPCPX and CPT were studied for their ability to reverse the locomotor suppression induced by the D(1) antagonist SCH 39166 (ecopipam) and the D(2) antagonist eticlopride. The D(1) and D(2) antagonists suppressed locomotion in all experiments. The adenosine A(2A) receptor antagonist MSX-3 (0.5-2.0 mg/kg IP) significantly reversed the suppression of locomotion induced by eticlopride. The non-selective adenosine antagonist caffeine (5.0-20.0 mg/kg IP) also reversed the effect of eticlopride, though the effect was not as robust as that seen with MSX-3. The adenosine A(1) antagonists DPCPX (0.375-1.5 mg/kg) and CPT (3.0-12.0 mg/kg IP) were unable to reverse the locomotor impairment elicited by eticlopride. Furthermore, the attenuation of locomotion induced by the D(1) antagonist could only be reversed by the highest dose of MSX-3, but not by caffeine, DPCPX or CPT. DA and adenosine receptor antagonists interact in the regulation of locomotor activation, but the nature of this interaction appears to depend upon the receptor selectivity profiles of the specific drugs being tested. |
Keywords: | Prosencephalon Animals Rats Rats, Sprague-Dawley Receptors, Dopamine Receptors, Purinergic P1 Dopamine Antagonists Analysis of Variance Behavior, Animal Motor Activity Dose-Response Relationship, Drug Drug Interactions Male Purinergic P1 Receptor Antagonists |
Rights: | © 2010 Elsevier B.V. All rights reserved. |
DOI: | 10.1016/j.bbr.2010.03.003 |
Published version: | http://dx.doi.org/10.1016/j.bbr.2010.03.003 |
Appears in Collections: | Anatomical Sciences publications Aurora harvest 4 |
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