Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/83597
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Type: Journal article
Title: New approaches to studying Plasmodium falciparum merozoite invasion and insights into invasion biology
Author: Boyle, M.
Wilson, D.
Beeson, J.
Citation: International Journal for Parasitology, 2013; 43(1):1-10
Publisher: Pergamon-Elsevier Science Ltd
Issue Date: 2013
ISSN: 0020-7519
1879-0135
Statement of
Responsibility: 
Michelle J. Boyle, Danny W. Wilson, James G. Beeson
Abstract: Merozoite invasion of human red blood cells by Plasmodium falciparum is essential for blood stage asexual replication and the development of malaria disease. Despite this, many of the processes involved in invasion are poorly understood. Recent advances have been made in methods to isolate viable merozoites for studies of invasion. The application of these approaches is providing new insights into the kinetics of invasion and merozoite survival, as well as proteins and interactions involved in invasion, and will facilitate the development and testing of anti-merozoite vaccines and the identification of invasion-inhibitory compounds with potential for drug development. This review discusses these recent advances and considers potential avenues for future research.
Keywords: Malaria
Plasmodium falciparum
Merozoite
Invasion
Inhibitors
Vaccines
Rights: © 2012 Australian Society for Parasitology Inc.
DOI: 10.1016/j.ijpara.2012.11.002
Grant ID: ARC
Published version: http://dx.doi.org/10.1016/j.ijpara.2012.11.002
Appears in Collections:Aurora harvest 4
Molecular and Biomedical Science publications

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