Adelaide Research & Scholarship
Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/87500
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| Type: | Journal article |
| Title: | mTOR's role in ageing: protein synthesis or autophagy? |
| Author: | Hands, S. Proud, C. Wyttenbach, A. |
| Citation: | Aging, 2009; 1(7):586-597 |
| Publisher: | Impact Journals |
| Issue Date: | 2009 |
| ISSN: | 1945-4589 1945-4589 |
| Statement of Responsibility: | Sarah L. Hands, Christopher G. Proud, Andreas Wyttenbach |
| Abstract: | The molecular and cellular mechanisms that regulate ageing are currently under scrutiny because ageing is linked to many human diseases. The nutrient sensing TOR pathway is emerging as a key regulator of ageing. TOR signaling is complex affecting several crucial cellular functions and two such functions, which show clear effects on ageing, are protein synthesis and autophagy. In this article we discuss the relative importance of both these processes in ageing, identify how TOR regulates translation and autophagy and speculate on links between the TOR signaling network and ageing pathways. |
| Keywords: | ageing TOR protein synthesis autophagy rapamycin |
| Rights: | ©2009 Hands et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| DOI: | 10.18632/aging.100070 |
| Published version: | http://www.impactaging.com/papers/v1/n7/abs/100070a.html |
| Appears in Collections: | Aurora harvest 2 Molecular and Biomedical Science publications |
Files in This Item:
| File | Description | Size | Format | |
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| hdl_87500.pdf | Published version | 774.02 kB | Adobe PDF | View/Open |
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