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Type: Journal article
Title: The role of Eph/ephrin molecules in stromal–hematopoietic interactions
Author: Nguyen, T.
Arthur, A.
Gronthos, S.
Citation: International Journal of Hematology, 2016; 103(2):145-154
Publisher: Springer
Issue Date: 2016
ISSN: 0925-5710
Statement of
Thao M. Nguyen, Agnieszka Arthur, Stan Gronthos
Abstract: Bone marrow mesenchymal stromal/stem cells(BMSC) are fundamental regulatory elements of the hematopoietic stem cell niche; however, the molecular signals that mediate BMSC support of hematopoiesis are poorly understood. Recent studies indicate that BMSC and hematopoietic stem/progenitors cells differentially express the Eph cell surface tyrosine kinase receptors, and their ephrinligands. Eph/ephrin interactions are thought to mediate cross-talk between BMSC and different hematopoietic cell populations to influence cell development, migration and function. This review summarizes Eph/ephrin interactions in the regulation of BMSC communication with hematopoietic stem/progenitor cells and discusses Eph/ephrintargeted therapeutic strategies that are currently being pursued for various hematotological malignancies.
Keywords: Haematopoietic stem cells niche; bone marrow mesenchymal/stem cells; stromal cells; Eph receptors; ephrin ligands
Rights: © The Japanese Society of Hematology 2015
RMID: 0030037207
DOI: 10.1007/s12185-015-1886-x
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Appears in Collections:Medicine publications

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