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|Title:||The role of Eph/ephrin molecules in stromal–hematopoietic interactions|
|Citation:||International Journal of Hematology, 2016; 103(2):145-154|
|Thao M. Nguyen, Agnieszka Arthur, Stan Gronthos|
|Abstract:||Bone marrow mesenchymal stromal/stem cells(BMSC) are fundamental regulatory elements of the hematopoietic stem cell niche; however, the molecular signals that mediate BMSC support of hematopoiesis are poorly understood. Recent studies indicate that BMSC and hematopoietic stem/progenitors cells differentially express the Eph cell surface tyrosine kinase receptors, and their ephrinligands. Eph/ephrin interactions are thought to mediate cross-talk between BMSC and different hematopoietic cell populations to influence cell development, migration and function. This review summarizes Eph/ephrin interactions in the regulation of BMSC communication with hematopoietic stem/progenitor cells and discusses Eph/ephrintargeted therapeutic strategies that are currently being pursued for various hematotological malignancies.|
|Keywords:||Haematopoietic stem cells niche; bone marrow mesenchymal/stem cells; stromal cells; Eph receptors; ephrin ligands|
|Rights:||© The Japanese Society of Hematology 2015|
|Appears in Collections:||Medicine publications|
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