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Type: Journal article
Title: Relating intercellular variability in nanoparticle uptake with biological consequence: a quantitative x-ray fluorescence study for radiosensitization of cells
Author: Turnbull, T.
Douglass, M.
Paterson, D.
Bezak, E.
Thierry, B.
Kempson, I.
Citation: Analytical Chemistry, 2015; 87(21):10693-10697
Publisher: American Chemical Society
Issue Date: 2015
ISSN: 0003-2700
Statement of
Tyron Turnbull, Michael Douglass, David Paterson, Eva Bezak, Benjamin Thierry, and Ivan Kempson
Abstract: Internalized gold nanoparticles were quantified in large numbers of individual prostate cancer cells using large area synchrotron X-ray fluorescence microscopy. Cells were also irradiated with a 6 MV linear accelerator to assess the biological consequence of radiosensitization with gold nanoparticles. A large degree of heterogeneity in nanoparticle uptake between cells resulted in influenced biological effect.
Keywords: Cells
Prostatic Neoplasms
Metal Nanoparticles
Rights: © 2015 American Chemical Society
DOI: 10.1021/acs.analchem.5b03183
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