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|Title:||Changes in lung tumor shape during respiration|
|Citation:||Physics in Medicine and Biology, 2012; 57(4):919-935|
|E. Kyriakou and D.R. McKenzie|
|Abstract:||Evidence that some lung tumors change shape during respiration is derived from respiratory gated CT data by statistical shape modeling and image manipulation. Some tumors behave as rigid objects while others show systematic shape changes. Two views of lung motion are presented to allow analysis of the results. In the first, lung motion is viewed as a wave motion in which inertial effects arising from mass are present and in the second it is a quasistatic motion in which the mass of the lung tissues is neglected. In the first scenario, the extremes of tumor compression and expansion are expected to correlate with maximum upward and downward velocity of the tumor, respectively. In the second, they should occur at end exhale and end inhale, respectively. An observed correlation between tumor strain and tumor velocity provides more support for the first view of lung motion and may explain why previous attempts at observing tumor shape changes during respiration have largely failed. The implications for the optimum gating of radiation therapy are discussed.|
|Rights:||© 2012 Institute of Physics and Engineering in Medicine|
|Appears in Collections:||Medicine publications|
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