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Type: Journal article
Title: Adult human dental pulp stem cells promote blood-brain barrier permeability through vascular endothelial growth factor-a expression
Author: Winderlich, J.
Kremer, K.
Koblar, S.
Citation: Journal of Cerebral Blood Flow and Metabolism, 2016; 36(6):1087-1097
Publisher: Nature Publishing Group
Issue Date: 2016
ISSN: 0271-678X
Statement of
Joshua N Winderlich, Karlea L Kremer and Simon A Koblar
Abstract: Stem cell therapy is a promising new treatment option for stroke. Intravascular administration of stem cells is a valid approach as stem cells have been shown to transmigrate the blood-brain barrier. The mechanism that causes this effect has not yet been elucidated. We hypothesized that stem cells would mediate localized discontinuities in the blood-brain barrier, which would allow passage into the brain parenchyma. Here, we demonstrate that adult human dental pulp stem cells express a soluble factor that increases permeability across an in vitro model of the blood-brain barrier. This effect was shown to be the result of vascular endothelial growth factor-a. The effect could be amplified by exposing dental pulp stem cell to stromal-derived factor 1, which stimulates vascular endothelial growth factor-a expression. These findings support the use of dental pulp stem cell in therapy for stroke.
Keywords: Dental pulp stem cells
blood–brain barrier
vascular endothelial growth factor
stromal-derived factor 1
in vitro
Rights: © Author(s) 2015
DOI: 10.1177/0271678X15608392
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