Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Adult human dental pulp stem cells promote blood-brain barrier permeability through vascular endothelial growth factor-a expression|
|Citation:||Journal of Cerebral Blood Flow and Metabolism, 2016; 36(6):1087-1097|
|Publisher:||Nature Publishing Group|
|Joshua N Winderlich, Karlea L Kremer and Simon A Koblar|
|Abstract:||Stem cell therapy is a promising new treatment option for stroke. Intravascular administration of stem cells is a valid approach as stem cells have been shown to transmigrate the blood-brain barrier. The mechanism that causes this effect has not yet been elucidated. We hypothesized that stem cells would mediate localized discontinuities in the blood-brain barrier, which would allow passage into the brain parenchyma. Here, we demonstrate that adult human dental pulp stem cells express a soluble factor that increases permeability across an in vitro model of the blood-brain barrier. This effect was shown to be the result of vascular endothelial growth factor-a. The effect could be amplified by exposing dental pulp stem cell to stromal-derived factor 1, which stimulates vascular endothelial growth factor-a expression. These findings support the use of dental pulp stem cell in therapy for stroke.|
|Keywords:||Dental pulp stem cells|
vascular endothelial growth factor
stromal-derived factor 1
|Rights:||© Author(s) 2015|
|Appears in Collections:||Aurora harvest 3|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.