Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/100609
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Type: Journal article
Title: Total synthesis of peniphenones A-D via biomimetic reactions of a common o-Quinone methide intermediate
Author: Spence, J.
George, J.
Citation: Organic Letters, 2015; 17(24):5970-5973
Publisher: American Chemical Society
Issue Date: 2015
ISSN: 1523-7060
1523-7052
Statement of
Responsibility: 
Justin T. J. Spence and Jonathan H. George
Abstract: The total synthesis of peniphenones A-D has been achieved via Michael reactions between appropriate nucleophiles and a common o-quinone methide intermediate. This strategy, which was based on a biosynthetic hypothesis, minimized the use of protecting groups and thus facilitated concise syntheses of the natural products. The most complex target, the benzannulated spiroketal peniphenone A, was synthesized enantioselectively in nine linear steps from commercially available starting materials.
Keywords: Mycobacterium tuberculosis
Description: Published: December 4, 2015
Rights: © 2015 American Chemical Society
RMID: 0030042126
DOI: 10.1021/acs.orglett.5b02902
Grant ID: http://purl.org/au-research/grants/arc/DE130100689
Appears in Collections:Chemistry publications

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