Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Type: Journal article
Title: The use of MALDI-MSI in the investigation of psychiatric and neurodegenerative disorders: a review
Author: Schubert, K.
Weiland, F.
Baune, B.
Hoffmann, P.
Citation: Proteomics, 2016; 16(11-12):1747-1758
Publisher: Wiley-VCH Verlag
Issue Date: 2016
ISSN: 1615-9853
Editor: Clench, M.
Statement of
Klaus Oliver Schubert, Florian Weiland, Bernhard T. Baune and Peter Hoffmann
Abstract: Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is a mass spectrometry technique used for the analysis of macromolecules on an intact tissue of interest, thereby allowing the assessment of molecular signatures in health and disease in the anatomical context. MALDI-MSI is increasingly used to investigate neurodegenerative and psychiatric disorders at the molecular level, including Alzheimer's disease (AD), Parkinson's disease (PD), and schizophrenia (SCZ). These illnesses are characterized by complex neuropathological processes, and conventional proteomic techniques investigating brain tissue homogenates have inherent limitations in determining the precise anatomical or cellular location of proteomic findings. In this article, we review MALDI-MSI studies on neurodegenerative and psychiatric disorders, and explore whether the technique could accelerate the translation of proteomic information into improved understanding and ultimately better therapeutic applications.
Keywords: Biomedicine; Imaging; MALDI-MSI; Mass spectrometry; Neurodegenerative disorders; Proteomics
Description: First published: 17 May 2016
Rights: © 2016 The Authors. Proteomics Published by Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
DOI: 10.1002/pmic.201500460
Appears in Collections:Aurora harvest 3
IPAS publications

Files in This Item:
File Description SizeFormat 
hdl_100726.pdfPublished version607.65 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.