Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/100789
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Type: Journal article
Title: Genome-wide patterns of selection in 230 ancient Eurasians
Author: Mathieson, I.
Lazaridis, I.
Rohland, N.
Mallick, S.
Patterson, N.
Roodenberg, S.
Harney, E.
Stewardson, K.
Fernandes, D.
Novak, M.
Sirak, K.
Gamba, C.
Jones, E.
Llamas, B.
Dryomov, S.
Pickrell, J.
Arsuaga, J.
De Castro, J.
Carbonell, E.
Gerritsen, F.
et al.
Citation: Nature, 2015; 528(7583):499-503
Publisher: Nature Publishing Group
Issue Date: 2015
ISSN: 0028-0836
1476-4687
Statement of
Responsibility: 
Iain Mathieson ... Bastien Llamas ... Alan Cooper ... Wolfgang Haak ... et al.
Abstract: Ancient DNA makes it possible to observe natural selection directly by analysing samples from populations before, during and after adaptation events. Here we report a genome-wide scan for selection using ancient DNA, capitalizing on the largest ancient DNA data set yet assembled: 230 West Eurasians who lived between 6500 and 300 bc, including 163 with newly reported data. The new samples include, to our knowledge, the first genome-wide ancient DNA from Anatolian Neolithic farmers, whose genetic material we obtained by extracting from petrous bones, and who we show were members of the population that was the source of Europe's first farmers. We also report a transect of the steppe region in Samara between 5600 and 300 bc, which allows us to identify admixture into the steppe from at least two external sources. We detect selection at loci associated with diet, pigmentation and immunity, and two independent episodes of selection on height.
Keywords: Bone and Bones
Description: Published online 23 November 2015
Rights: © 2015 Macmillan Publishers Limited. All rights reserved
RMID: 0030039700
DOI: 10.1038/nature16152
Grant ID: http://purl.org/au-research/grants/arc/DP130102158
Appears in Collections:Australian Centre for Ancient DNA publications

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