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Type: Journal article
Title: Experimental study of electrolysis-induced hepatic necrosis
Author: Robertson, G.
Wemyss-Holden, S.
Dennison, A.
Hall, P.
Baxter, P.
Maddern, G.
Citation: British Journal of Surgery, 1998; 85(9):1212-1216
Issue Date: 1998
ISSN: 0007-1323
Statement of
G. S. M. Robertson, S. A. Wemyss-Holden, A. R. Dennison, P. De La M. Hall, P. Baxter, and Professor G. J. Maddern
Abstract: Background: One of the most promising but unexplored methods for treating patients with irresectable liver tumours is electrolysis. This study examined the effect of increasing ‘current dose’ on the volume of the lesion induced in normal rat liver. Methods: A direct current generator, connected to platinum electrodes implanted in the rat liver, was used to examine the effect of (1) varying current doses from 1 to 5 coulombs and (2) electrode separation (2 or 20 mm), on the volume of liver necrosis. Results: There was a significant correlation (P < 0·001) between the current dose and the volume of necrosis produced for each electrode separation. Placing the electrodes 2 mm apart resulted in smaller total volumes of necrosis than placing them 20 mm apart when anode lesions were significantly larger than cathode lesions (P < 0·05). Liver enzymes (aspartate aminotransferase, alanine aminotransferase) were significantly raised 1 day after treatment (P < 0·001) and predicted the total volume of hepatic necrosis (P < 0·001). Conclusion: Predictable and reproducible areas of liver necrosis are produced with electrolysis. If these results extrapolate to larger animal models, this technique has potential for patients with irresectable primary and secondary liver tumours.
Keywords: Electrolysis
Liver -- Diseases
Description: Article first published online: 13 JAN 2003
Rights: © 1998 British Journal of Surgery Society Ltd
DOI: 10.1046/j.1365-2168.1998.00806.x
Appears in Collections:Aurora harvest 2
Surgery publications

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