Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/101249
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dc.contributor.authorGugusheff, J.en
dc.contributor.authorSim, P.en
dc.contributor.authorKheng, A.en
dc.contributor.authorGentili, S.en
dc.contributor.authorAl-Nussairawi, M.en
dc.contributor.authorBrand-Miller, J.en
dc.contributor.authorMuhlhausler, B.en
dc.date.issued2016en
dc.identifier.citationJournal of Developmental Origins of Health and Disease, 2016; 7(3):320-329en
dc.identifier.issn2040-1744en
dc.identifier.issn2040-1752en
dc.identifier.urihttp://hdl.handle.net/2440/101249-
dc.descriptionFirst published online 10 December 2015en
dc.description.abstractClinical studies have reported beneficial effects of a maternal low glycaemic index (GI) diet on pregnancy and neonatal outcomes, but the impact of the diet on the offspring in later life, and the mechanisms underlying these effects, remain unclear. In this study, Albino Wistar rats were fed either a low GI (n = 14) or high GI (n = 14) diet during pregnancy and lactation and their offspring weaned onto either the low or high GI diet. Low GI dams had better glucose tolerance (AUC[glucose], 1322 ± 55 v. 1523 ± 72 mmol min/l, P< 0.05) and a lower proportion of visceral fat (19.0 ± 2.9 v. 21.7 ± 3.8% of total body fat, P<0.05) compared to high GI dams. Female offspring of low GI dams had lower visceral adiposity (0.45 ± 0.03 v. 0.53 ± 0.03% body weight, P< 0.05) and higher glucose tolerance (AUC[glucose], 1243 ± 29 v. 1351 ± 39 mmol min/l, P<0.05) at weaning, as well as lower hepatic PI3K-p85 mRNA at 12 weeks of age. No differences in glucose tolerance or hepatic gene expression were observed in male offspring, but the male low GI offspring did have reduced hepatic lipid content at weaning. These findings suggest that consuming a low GI diet during pregnancy and lactation can improve glucose tolerance and reduce visceral adiposity in the female offspring at weaning, and may potentially produce long-term reductions in the hepatic lipogenic capacity of these offspring.en
dc.description.statementofresponsibilityJ. Gugusheff, P. Sim, A. Kheng, S. Gentili, M. Al-Nussairawi, J. Brand-Miller and B. Muhlhausleren
dc.language.isoenen
dc.publisherCambridge University Pressen
dc.rights© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2015en
dc.subjectfat mass; insulin resistance; programmingen
dc.titleThe effect of maternal and post-weaning low and high glycaemic index diets on glucose tolerance, fat deposition and hepatic function in rat offspringen
dc.typeJournal articleen
dc.identifier.rmid0030040868en
dc.identifier.doi10.1017/S2040174415007965en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1004211en
dc.identifier.pubid226534-
pubs.library.collectionAgriculture, Food and Wine publicationsen
pubs.library.teamDS03en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidMuhlhausler, B. [0000-0002-9021-6790]en
Appears in Collections:Agriculture, Food and Wine publications

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