Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/101288
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Type: Journal article
Title: Comorbid externalising behaviour in AD/HD: evidence for a distinct pathological entity in adolescence
Author: Perera, S.
Crewther, D.
Croft, R.
Keage, H.
Hermens, D.
Clark, C.
Citation: PLoS ONE, 2012; 7(9):e41407-1-e41407-12
Publisher: Public Library of Science
Issue Date: 2012
ISSN: 1932-6203
1932-6203
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Responsibility: 
Sharnel Perera, David Crewther, Rodney Croft, Hannah Keage, Daniel Hermens, C. Richard Clark
Abstract: While the profiling of subtypes of Attention Deficit Hyperactivity Disorder (AD/HD) have been the subject of considerable scrutiny, both psychometrically and psychophysiologically, little attention has been paid to the effect of diagnoses comorbid with AD/HD on such profiles. This is despite the greater than 80% prevalence of comorbidity under the DSM-IV-TR diagnostic definitions. Here we investigate the event related potential (ERP) and psychometric profiles of Controls, AD/HD, and comorbid AD/HD (particularly AD/HD+ODD/CD) groups on six neurocognitive tasks thought to probe the constructs of selective and sustained attention, response inhibition and executive function. Data from 29 parameters extracted from a child group (age range 6 to 12; 52 Controls and 64 AD/HD) and from an adolescent group (age range 13 to 17; 79 Controls and 88 AD/HD) were reduced via a Principal Components Analysis, the 6 significant eigenvectors then used as determinants of cluster membership via a Two-Step Cluster Analysis. Two clusters were found in the analysis of the adolescent age group--a cluster dominated by Control and AD/HD participants without comorbidity, while the second cluster was dominated by AD/HD participants with externalising comorbidity (largely oppositional defiant/conduct disorder ODD/CD). A similar segregation within the child age group was not found. Further analysis of these objectively determined clusters in terms of their clinical diagnoses indicates a significant effect of ODD/CD comorbidity on a concurrent AD/HD diagnosis. We conclude that comorbid externalising behaviour in AD/HD constitutes a distinct pathological entity in adolescence.
Keywords: Externalising behaviour; AD/HD
Rights: © 2012 Perera et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
RMID: 0030050739
DOI: 10.1371/journal.pone.0041407
Grant ID: http://purl.org/au-research/grants/arc/LP0349079
Appears in Collections:Psychology publications

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