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Type: Journal article
Title: High mitochondrial accumulation of new gadolinium(III) agents within tumour cells
Author: Morrison, D.
Aitken, J.
De Jonge, M.
Ioppolo, J.
Harris, H.
Rendina, L.
Citation: Chemical Communications, 2014; 50(18):2252-2254
Publisher: Royal Society of Chemistry
Issue Date: 2014
ISSN: 1359-7345
Statement of
Daniel E. Morrison, Jade B. Aitken, Martin D. de Jonge, Joseph A. Ioppolo, Hugh H. Harris and Louis M. Rendina
Abstract: The first bifunctional GdIII complexes covalently bound to arylphosphonium cations and the first tumour-cell selective mitochondrial agents designed for potential application in binary cancer therapies are reported. The highest in vitro cellular uptake for any Gd complex reported to date is described, with levels exceeding 1010 Gd atoms per tumour cell.
Keywords: Cell Line, Tumor; Mitochondria; Humans; Neoplasms; Gadolinium; Organometallic Compounds; Antineoplastic Agents; Drug Screening Assays, Antitumor; Molecular Structure; Structure-Activity Relationship; Dose-Response Relationship, Drug; Drug Design
Rights: This journal is © The Royal Society of Chemistry 2014
RMID: 0030015008
DOI: 10.1039/c3cc46903d
Appears in Collections:Chemistry publications

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