Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/101452
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Type: Journal article
Title: Linking metabolism to membrane signaling: the GABA–malate connection
Author: Gilliham, M.
Tyerman, S.
Citation: Trends in Plant Science, 2016; 21(4):295-301
Publisher: Elsevier
Issue Date: 2016
ISSN: 1360-1385
1878-4372
Statement of
Responsibility: 
Matthew Gilliham and Stephen D. Tyerman
Abstract: γ-Aminobutyric acid (GABA) concentration increases rapidly in tissues when plants encounter abiotic or biotic stress, and GABA manipulation affects growth. This, coupled to GABA's well-described role as a neurotransmitter in mammals, led to over a decade of speculation that GABA is a signal in plants. The discovery of GABA-regulated anion channels in plants provides compelling mechanistic proof that GABA is a legitimate plant-signaling molecule. Here we examine research avenues unlocked by this finding and propose that these plant 'GABA receptors' possess novel properties ideally suited to translating changes in metabolic status into physiological responses. Specifically, we suggest they have a role in signaling altered cycling of tricarboxylic acid (TCA) intermediates during stress via eliciting changes in electrical potential differences across membranes.
Keywords: Plants; gamma-Aminobutyric Acid; Malates; Receptors, GABA; Plant Proteins; Signal Transduction; Membrane Potentials; Citric Acid Cycle; Phenotype; Stress, Physiological
Rights: © 2015 Elsevier Ltd. All rights reserved.
RMID: 0030041514
DOI: 10.1016/j.tplants.2015.11.011
Grant ID: http://purl.org/au-research/grants/arc/FT130100709
http://purl.org/au-research/grants/arc/CE140100008
Appears in Collections:Agriculture, Food and Wine publications

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