Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Type: Journal article
Title: Antibacterial plasma polymer films conjugated with phospholipid encapsulated silver nanoparticles
Author: Taheri, S.
Cavallaro, A.
Christo, S.
Majewski, P.
Barton, M.
Hayball, J.
Vasilev, K.
Citation: ACS Biomaterials Science and Engineering, 2015; 1(12):1278-1286
Publisher: American Chemical Society
Issue Date: 2015
ISSN: 2373-9878
Statement of
Shima Taheri, Alex Cavallaro, Susan N. Christo, Peter Majewski, Mary Barton, John D. Hayball and Krasimir Vasilev
Abstract: Medical device associated infections are a persistent medical problem which has not found a comprehensive solution yet. Over the last decades, there have been intense research efforts toward developing antibacterial coatings that could potentially improve medical outcomes. Silver nanoparticles have attracted a great deal of attention as a potent alternative to conventional antibiotics. Herein, we present a biologically inspired approach to synthesize phospholipid encapsulated silver nanoparticles and their surface immobilization to a functional plasma polymer interlayer to generate antibacterial coatings. The antibacterial efficacy of the coatings was evaluated against three medically relevant pathogens including the Gram-positive Staphylococcus aureus and Staphylococcus epidermidis, and the Gram-negative Pseudomonas aeruginosa. The innate immune response to the coatings was assessed in vitro using primary bone marrow derived macrophages (BMDM). Any potential cytotoxicity was studied with primary human dermal fibroblasts (HDFs). Overall, the coatings had excellent inhibition of bacterial growth. We also observed reduced expression of pro-inflammatory cytokines from BMDM which suggests a reduced inflammatory response. The combined properties of coatings developed in this study may make them a good candidate for application on medical devices such as catheters and wound dressings.
Keywords: Antibacterial coating; inflammatory response; phospholipid bilayer; silver nanoparticles
Rights: Copyright © 2015 American Chemical Society
DOI: 10.1021/acsbiomaterials.5b00338
Grant ID:
Appears in Collections:Aurora harvest 7
Medicine publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.