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Type: Journal article
Title: Androgen control of lipid metabolism in prostate cancer: novel insights and future applications
Author: Butler, L.
Centenera, M.
Swinnen, J.
Citation: Endocrine-Related Cancer, 2016; 23(5):219-227
Publisher: Bioscientifica
Issue Date: 2016
ISSN: 1351-0088
Statement of
Lisa M Butler, Margaret M Centenera, Johannes V Swinnen
Abstract: One of the most typical hallmarks of prostate cancer cells is their exquisite dependence on androgens, which is the basis of the widely applied androgen deprivation therapy. Among the variety of key cellular processes and functions that are regulated by androgens, lipid metabolism stands out by its complex regulation and its many intricate links with cancer cell biology. Here, we review our current knowledge on the links between androgens and lipid metabolism in prostate cancer, and highlight recent developments and insights into the links between key oncogenic stimuli and altered lipid synthesis and/or uptake that may hold significant potential for biomarker development and provide new vulnerabilities for therapeutic intervention.
Keywords: Lipid metabolism; phospholipids; androgens; lipogenic enzymes; prostate cancer; lipidomics
Rights: © 2016 Society for Endocrinology
RMID: 0030047228
DOI: 10.1530/ERC-15-0556
Grant ID:
Appears in Collections:Medicine publications

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