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|Title:||In situ transformation of chitosan films into microtubular structures on the surface of nanoengineered titanium implants|
|Citation:||Biomacromolecules, 2016; 17(4):1261-1271|
|Publisher:||American Chemical Society|
|Karan Gulati, Lucas Johnson, Ramesh Karunagaran, David Findlay and Dusan Losic|
|Abstract:||There is considerable interest in combining bioactive polymers such as chitosan with titanium bone implants to promote bone healing and address therapeutic needs. However, the fate of these biodegradable polymers especially on titanium implants is not fully explored. Here we report in situ formation of chitosan microtube (CMT) structures from chitosan films on the implant surface with titania nanotubes (TNTs) layer, based on phosphate buffer-induced transformation and precipitation process. We have comprehensively analyzed this phenomenon and the factors that influence CMT formation, including substrate topography, immersion solution and its pH, effect of coating thickness, and time of immersion. Significance of reported in situ formation of chitosan microtubes on the TNTs surface is possibly to tailor properties of implants with favorable micro and nano morphology using a self-ordering process after the implant's insertion.|
|Keywords:||Humans; Titanium; Ferric Compounds; Polymers; Chitosan; Biocompatible Materials; Coated Materials, Biocompatible; Drug Delivery Systems; Tissue Engineering; Prostheses and Implants; Bone Regeneration; Surface Properties; Metal Nanoparticles|
|Rights:||Copyright © 2016 American Chemical Society|
|Appears in Collections:||Chemical Engineering publications|
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