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Type: Journal article
Title: In situ transformation of chitosan films into microtubular structures on the surface of nanoengineered titanium implants
Author: Gulati, K.
Johnson, L.
Karunagaran, R.
Findlay, D.
Losic, D.
Citation: Biomacromolecules, 2016; 17(4):1261-1271
Publisher: American Chemical Society
Issue Date: 2016
ISSN: 1525-7797
Statement of
Karan Gulati, Lucas Johnson, Ramesh Karunagaran, David Findlay and Dusan Losic
Abstract: There is considerable interest in combining bioactive polymers such as chitosan with titanium bone implants to promote bone healing and address therapeutic needs. However, the fate of these biodegradable polymers especially on titanium implants is not fully explored. Here we report in situ formation of chitosan microtube (CMT) structures from chitosan films on the implant surface with titania nanotubes (TNTs) layer, based on phosphate buffer-induced transformation and precipitation process. We have comprehensively analyzed this phenomenon and the factors that influence CMT formation, including substrate topography, immersion solution and its pH, effect of coating thickness, and time of immersion. Significance of reported in situ formation of chitosan microtubes on the TNTs surface is possibly to tailor properties of implants with favorable micro and nano morphology using a self-ordering process after the implant's insertion.
Keywords: Humans
Ferric Compounds
Biocompatible Materials
Coated Materials, Biocompatible
Drug Delivery Systems
Tissue Engineering
Prostheses and Implants
Bone Regeneration
Surface Properties
Metal Nanoparticles
Rights: Copyright © 2016 American Chemical Society
DOI: 10.1021/acs.biomac.5b01037
Grant ID:
Appears in Collections:Aurora harvest 3
Chemical Engineering publications

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