Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/101708
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Type: Journal article
Title: Maternal marijuana use has independent effects on risk for spontaneous preterm birth but not other common late pregnancy complications
Author: Leemaqz, S.
Dekker, G.
McCowan, L.
Kenny, L.
Myers, J.
Simpson, N.
Poston, L.
Roberts, C.
Citation: Reproductive Toxicology, 2016; 62:77-86
Publisher: Elsevier
Issue Date: 2016
ISSN: 0890-6238
1873-1708
Statement of
Responsibility: 
Shalem Y. Leemaqz, Gustaaf A. Dekker, Lesley M. McCowan, Louise C. Kenny, Jenny E. Myers, Nigel A.B. Simpson, Lucilla Poston, Claire T. Roberts, On behalf of the SCOPE Consortium
Abstract: Widespread legalisation of marijuana raises safety concerns for its use in pregnancy. This study investigated the association of marijuana use prior to and during pregnancy with pregnancy outcomes in a prospective cohort of 5588 nulliparous women from the international SCOPE study. Women were assessed at 15 ± 1 and 20 ± 1 weeks’ gestation. Cases [278 Preeclampsia, 470 gestational hypertension, 633 small-for-gestational-age, 236 spontaneous preterm births (SPTB), 143 gestational diabetes] were compared separately with 4114 non-cases. Although the numbers are small, continued maternal marijuana use at 20 weeks’ gestation was associated with SPTB independent of cigarette smoking status [adj OR 2.28 (95% CI:1.45–3.59)] and socioeconomic index (SEI) [adj OR 2.17 (95% CI:1.41–3.34)]. When adjusted for maternal age, cigarette smoking, alcohol and SEI, continued maternal marijuana use at 20 weeks’ gestation had a greater effect size [adj OR 5.44 (95% CI 2.44–12.11)]. Our data indicate that increasing use of marijuana among young women of reproductive age is a major public health concern.
Keywords: Marijuana; smoking; BMI; pregnancy outcome; spontaneous preterm birth
Rights: © 2016 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-NDlicense (http://creativecommons.org/licenses/by-nc-nd/4.0/).
RMID: 0030047208
DOI: 10.1016/j.reprotox.2016.04.021
Grant ID: http://purl.org/au-research/grants/nhmrc/1020749
http://purl.org/au-research/grants/nhmrc/519225
Appears in Collections:Medicine publications

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