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Type: Journal article
Title: Ecdysone-mediated programmed cell death in Drosophila
Author: Nicolson, S.
Denton, D.
Kumar, S.
Citation: The International Journal of Developmental Biology, 2015; 59(1-3):23-32
Publisher: University of the Basque Country Press (UBC Press)
Issue Date: 2015
ISSN: 0214-6282
Statement of
Shannon Nicolson, Donna Denton and Sharad Kumar
Abstract: During Drosophila development, the steroid hormone ecdysone plays a key role in the transition from embryo into larva and then into pupa. It is during larval-pupal metamorphosis that extensive programmed cell death occurs to remove large obsolete larval tissues. During this transition, ecdysone pulses control the expression of specific transcription factors which drive the expression of key genes involved in cell death, thus spatially and temporally controlling programmed cell death. Ecdysone also controls cell death in specific larval and adult tissues. This review focuses on the current knowledge of ecdysone-mediated cell death in Drosophila.
Keywords: programmed cell death; ecydsone; transcription; apoptosis; autophagy
Rights: © 2015 UBC Press
DOI: 10.1387/ijdb.150055sk
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