Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/101854
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of antibody CSL362 |
Author: | Broughton, S. Hercus, T. Nero, T. Dhagat, U. Owczarek, C. Hardy, M. Fabri, L. Scotney, P. Nash, A. Wilson, N. Lopez, A. Parker, M. |
Citation: | Acta Crystallographica Section F: Structural Biology Communications, 2014; 70(3):358-361 |
Publisher: | International Union of Crystallography |
Issue Date: | 2014 |
ISSN: | 2053-230X 2053-230X |
Statement of Responsibility: | Sophie E. Broughton, Timothy R. Hercus, Tracy L. Nero, Urmi Dhagat, Catherine M. Owczarek, Matthew P. Hardy, Louis J. Fabri, Pierre D. Scotney, Andrew D. Nash, Nicholas J. Wilson, Angel F. Lopez and Michael W. Parkerar |
Abstract: | Interleukin-3 (IL-3) is a member of the beta common family of cytokines that regulate multiple functions of myeloid cells. The IL-3 receptor-specific alpha subunit (IL3Rα) is overexpressed on stem cells/progenitor cells of patients with acute myeloid leukaemia, where elevated receptor expression correlates clinically with a reduced patient survival rate. The monoclonal antibody (MAb) CSL362 is a humanized MAb derived from the murine MAb 7G3, originally identified for its ability to specifically recognize the human IL-3 receptor and for blocking the signalling of IL-3 in myeloid and endothelial cells. In order to elucidate the molecular mechanism of CSL362 antagonism, a preliminary structure of human IL3Rα in complex with the MAb CSL362 has been determined. |
Keywords: | Crystallization |
Rights: | © 2014 International Union of Crystallography All rights reserved |
DOI: | 10.1107/S2053230X14002593 |
Grant ID: | NHMRC |
Published version: | http://dx.doi.org/10.1107/s2053230x14002593 |
Appears in Collections: | Aurora harvest 7 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.