Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
Full metadata record
|dc.identifier.citation||World Journal of Biological Psychiatry, 2014; 15(7):579-584||en|
|dc.description.abstract||OBJECTIVES: Research studies have reported impressive antidepressant effects with ketamine but significant knowledge gaps remain over the best method of administering ketamine, and the relationships between dose, antidepressant response and adverse effects. METHODS: In this pilot dose-finding study, the efficacy and tolerability of ketamine given by rapid intravenous (i.v.) infusion were assessed in a double-blind, placebo-controlled, crossover design, in four subjects with treatment- resistant depression. Each subject received up to four i.v. doses of ketamine (0.1, 0.2, 0.3, 0.4 mg/kg), given over 2-5 min, 1 week apart, and one randomly inserted placebo treatment. RESULTS: Three of four subjects achieved antidepressant response (≥ 50% decrease in Montgomery-Asberg Depression Rating Scale scores), two at the minimum 0.1 mg/kg dose, though all relapsed within a week. For two subjects, the greatest improvement occurred at the highest dose received. Rapid infusion over 2 min led to significant adverse psychotomimetic effects which also increased proportionately with ketamine dosage. CONCLUSIONS: This is the first trial to present dose-response data of ketamine efficacy and psychomimetic effects in depressed subjects. Antidepressant efficacy may be dose-related. Psychotomimetic effects were dose-related. Rapid infusion over 2 min may not be a feasible clinical approach to treatment, given poor tolerability.||en|
|dc.description.statementofresponsibility||Rosalyn Lai, Natalie Katalinic, Paul Glue, Andrew A. Somogyi, Philip B. Mitchell, John Leyden, Simon Harper, and Colleen K. Loo||en|
|dc.publisher||Taylor and Francis||en|
|dc.rights||© 2014 Informa Healthcare||en|
|dc.subject||Ketamine; depression; dose-response relationship; drug-related side effects and adverse reactions; intravenous administration||en|
|dc.title||Pilot dose-response trial of I.V. ketamine in treatment-resistant depression||en|
|dc.identifier.orcid||Somogyi, A. [0000-0003-4779-0380]||en|
|Appears in Collections:||Medicine publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.