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|Title:||Imatinib-induced gastric antral vascular ectasia in three patients with chronic myeloid leukaemia|
|Citation:||International Journal of Hematology, 2015; 102(5):639-642|
|Jeremy Ong, David Yeung, Robin Filshie, Timothy P. Hughes, Harshal Nandurkar|
|Abstract:||Imatinib is generally well tolerated, but gastric antral vascular ectasia (GAVE) remains a rare but significant complication of imatinib therapy. Whilst this complication has been described in other disease settings, only one other case of GAVE has been reported in a chronic myeloid leukaemia (CML) patient receiving imatinib. Herein, we present three CML patients with GAVE complicating imatinib therapy. In all cases, GAVE resolved only with cessation of imatinib. This confirms a causal relationship between GAVE and imatinib. GAVE should be considered as a possible cause of anaemia and upper gastrointestinal bleeding in patients receiving imatinib therapy.|
|Keywords:||Chronic myeloid leukaemia; Tyrosine kinase inhibitor; Imatinib; Gastric antral vascular ectasia|
|Description:||Published online: 2 July 2015|
|Rights:||© The Japanese Society of Hematology 2015|
|Appears in Collections:||Molecular and Biomedical Science publications|
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