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Type: Journal article
Title: Serum S-adenosylmethionine, but not methionine, increases in response to overfeeding in humans
Author: Elshorbagy, A.
Jernerén, F.
Samocha-Bonet, D.
Refsum, H.
Heilbronn, L.
Citation: Nutrition and Diabetes, 2016; 6(1):e192-1-e192-4
Publisher: Nature Publishing Group
Issue Date: 2016
ISSN: 2044-4052
Statement of
A K Elshorbagy, F Jernerén, D Samocha-Bonet, H Refsum and L K Heilbronn
Abstract: Background: Plasma concentration of the methyl donor S-adenosylmethionine (SAM) is linearly associated with body mass index (BMI) and fat mass. As SAM is a high-energy compound and a sensor of cellular nutrient status, we hypothesized that SAM would increase with overfeeding. Methods: Forty normal to overweight men and women were overfed by 1250 kcal per day for 28 days. Results: Serum SAM increased from 106 to 130 nmol/l (P=0.006). In stratified analysis, only those with weight gain above the median (high-weight gainers; average weight gain 3.9±0.3 kg) had increased SAM (+42%, P=0.001), whereas low-weight gainers (weight gain 1.5±0.2 kg) did not (Pinteraction=0.018). Overfeeding did not alter serum concentrations of the SAM precursor, methionine or the products, S-adenosyl-homocysteine and homocysteine. The SAM/SAH (S-adenosylhomocysteine) ratio was unchanged in the total population, but increased in high-weight gainers (+52%, P=0.006, Pinteraction =0.005). Change in SAM correlated positively with change in weight (r=0.33, P=0.041) and fat mass (r=0.44, P=0.009), but not with change in protein intake or plasma methionine, glucose, insulin or low-density lipoprotein (LDL)-cholesterol. Conclusion: Overfeeding raised serum SAM in proportion to the fat mass gained. The increase in SAM may help stabilize methionine levels, and denotes a responsiveness of SAM to nutrient state in humans. The role of SAM in human energy metabolism deserves further attention.
Keywords: S-Adenosylmethionine
Rights: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit by/4.0/
RMID: 0030042383
DOI: 10.1038/nutd.2015.44
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