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Type: Journal article
Title: Liberal glycemic control in critically Ill patients with type 2 diabetes: an exploratory study
Author: Kar, P.
Plummer, M.P.
Bellomo, R.
Jenkins, A.J.
Januszewski, A.S.
Chapman, M.J.
Jones, K.L.
Horowitz, M.
Deane, A.M.
Citation: Critical Care Medicine, 2016; 44(9):1695-1703
Publisher: Lippincott Williams & Wilkins
Issue Date: 2016
ISSN: 0090-3493
Statement of
Palash Kar, Mark P. Plummer, Rinaldo Bellomo, MD, Alicia J. Jenkins, Andrzej S. Januszewski, Marianne J. Chapman, Karen L. Jones, Michael Horowitz, Adam M. Deane
Abstract: Objectives: The optimal blood glucose target in critically ill patients with preexisting diabetes and chronic hyperglycemia is unknown. In such patients, we aimed to determine whether a “liberal” approach to glycemic control would reduce hypoglycemia and glycemic variability and appear safe. Design: Prospective, open-label, sequential-period exploratory study. Setting: Medical-surgical ICU. Patients: During sequential 6-month periods, we studied 83 patients with preexisting type 2 diabetes and chronic hyperglycemia (glycated hemoglobin, ≥ 7.0% at ICU admission). Intervention: During the “standard care” period, 52 patients received insulin to treat blood glucose concentrations greater than 10 mmol/L whereas during the “liberal” period, 31 patients received insulin to treat blood glucose concentrations greater than 14 mmol/L. Measurements and Main Results: Time-weighted mean glucose concentrations and the number and duration of moderate (< 4.0 mmol/L) and severe (≤ 2.2 mmol/L) hypoglycemic episodes were recorded, with moderate and severe hypoglycemic episodes grouped together. Glycemic variability was assessed by calculating the coefficient of variability for each patient. Safety was evaluated using clinical outcomes and plasma concentrations of markers of inflammation, glucose-turnover, and oxidative stress. Mean glucose (TWglucoseday 0–7, standard care: 9.3 [1.8] vs liberal: 10.3 [2.1] mmol/L; p = 0.02) and nadir blood glucose (4.4 [1.5] vs 5.5 [1.6] mmol/L; p < 0.01) were increased during the liberal period. There was a signal toward reduced risk of moderate-severe hypoglycemia (relative risk: liberal compared with standard care: 0.47 [95% CI, 0.19–1.13]; p = 0.09). Ten patients (19%) during the standard period and one patient (3%) during the liberal period had recurrent episodes of moderatesevere hypoglycemia. Liberal therapy reduced glycemic variability (coefficient of variability, 33.2% [12.9%] vs 23.8% [7.7%]; p < 0.01). Biomarker data and clinical outcomes were similar. Conclusions: In critically ill patients with type 2 diabetes and chronic hyperglycaemia, liberal glycemic control appears to attenuate glycemic variability and may reduce the prevalence of moderate-severe hypoglycemia.
Keywords: Humans
Diabetes Mellitus, Type 2
Chronic Disease
Critical Illness
Blood Glucose
Hypoglycemic Agents
Critical Care
Prospective Studies
Middle Aged
Controlled Before-After Studies
Glycated Hemoglobin
Rights: Copyright © 2016 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.
DOI: 10.1097/CCM.0000000000001815
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