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https://hdl.handle.net/2440/102432
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dc.contributor.author | Scolaro, L. | - |
dc.contributor.author | Lorenser, D. | - |
dc.contributor.author | Madore, W. | - |
dc.contributor.author | Kirk, R. | - |
dc.contributor.author | Kramer, A. | - |
dc.contributor.author | Yeoh, G. | - |
dc.contributor.author | Godbout, N. | - |
dc.contributor.author | Sampson, D. | - |
dc.contributor.author | Boudoux, C. | - |
dc.contributor.author | McLaughlin, R. | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Biomedical Optics Express, 2015; 6(5):1767-1781 | - |
dc.identifier.issn | 2156-7085 | - |
dc.identifier.issn | 2156-7085 | - |
dc.identifier.uri | http://hdl.handle.net/2440/102432 | - |
dc.description.abstract | Molecular imaging using optical techniques provides insight into disease at the cellular level. In this paper, we report on a novel dualmodality probe capable of performing molecular imaging by combining simultaneous three-dimensional optical coherence tomography (OCT) and two-dimensional fluorescence imaging in a hypodermic needle. The probe, referred to as a molecular imaging (MI) needle, may be inserted tens of millimeters into tissue. The MI needle utilizes double-clad fiber to carry both imaging modalities, and is interfaced to a 1310-nm OCT system and a fluorescence imaging subsystem using an asymmetrical double-clad fiber coupler customized to achieve high fluorescence collection efficiency. We present, to the best of our knowledge, the first dual-modality OCT and fluorescence needle probe with sufficient sensitivity to image fluorescently labeled antibodies. Such probes enable high-resolution molecular imaging deep within tissue. | - |
dc.description.statementofresponsibility | Loretta Scolaro, Dirk Lorenser, Wendy-Julie Madore, Rodney W. Kirk, Anne S. Kramer, George C. Yeoh, Nicolas Godbout, David D. Sampson, Caroline Boudoux, and Robert A. McLaughlin | - |
dc.language.iso | en | - |
dc.publisher | Optical Society of America | - |
dc.rights | ©2015 Optical Society of America. Open Access | - |
dc.source.uri | http://dx.doi.org/10.1364/boe.6.001767 | - |
dc.subject | (110.2350) Fiber optics imaging | - |
dc.subject | (170.0180) Microscopy | - |
dc.subject | (170.2520) Fluorescence microscopy | - |
dc.subject | (170.4500) Optical coherence tomography | - |
dc.title | Molecular imaging needles: dual-modality optical coherence tomography and fluorescence imaging of labeled antibodies deep in tissue | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1364/BOE.6.001767 | - |
dc.relation.grant | ARC | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | McLaughlin, R. [0000-0001-6947-5061] | - |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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